Overweight/obesity in young adulthood interacts with aspects of EBV infection in MS etiology.
Antibodies, Viral
/ blood
Body Mass Index
Case-Control Studies
Epstein-Barr Virus Nuclear Antigens
/ immunology
Female
HLA-DRB1 Chains
/ genetics
Humans
Infectious Mononucleosis
/ complications
Male
Multiple Sclerosis
/ epidemiology
Obesity
/ complications
Overweight
/ complications
Risk Factors
Sweden
Young Adult
Journal
Neurology(R) neuroimmunology & neuroinflammation
ISSN: 2332-7812
Titre abrégé: Neurol Neuroimmunol Neuroinflamm
Pays: United States
ID NLM: 101636388
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
20
04
2020
accepted:
11
09
2020
entrez:
19
1
2021
pubmed:
20
1
2021
medline:
13
10
2021
Statut:
epublish
Résumé
Because obesity affects the cellular immune response to infections, we aimed to investigate whether high body mass index (BMI) in young adulthood and high Epstein-Barr nuclear antigen 1 (EBNA-1) antibody levels interact with regard to MS risk. We also aimed at exploring potential 3-way interactions between BMI at age 20 years, aspects of Epstein-Barr virus (EBV) infection (high EBNA-1 antibody levels and infectious mononucleosis [IM] history, respectively) and the human leukocyte antigen Using Swedish population-based case-control studies (5,460 cases and 7,275 controls), we assessed MS risk in relation to interactions between overweight/obesity at age 20 years, IM history, EBNA-1 levels, and Overweight/obesity, compared with normal weight, interacted significantly with high (>50th percentile) EBNA-1 antibody levels (attributable proportion due to interaction 0.2, 95% CI 0.1-0.4). The strength of the interaction increased with higher category of EBNA-1 antibody levels. Furthermore, 3-way interactions were present between With regard to MS risk, overweight/obesity in young adulthood acts synergistically with both aspects of EBV infection, predominantly among those with a genetic susceptibility to the disease. The obese state both induces a chronic immune-mediated inflammation and affects the cellular immune response to infections, which may contribute to explain our findings.
Identifiants
pubmed: 33465039
pii: 8/1/e912
doi: 10.1212/NXI.0000000000000912
pmc: PMC7803338
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Epstein-Barr Virus Nuclear Antigens
0
HLA-DRB1 Chains
0
HLA-DRB1*15:01 antigen
0
EBV-encoded nuclear antigen 1
O5GA75RST7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
Références
Eur J Neurol. 2012 Jul;19(7):955-62
pubmed: 22289117
Neurology. 2009 Nov 10;73(19):1543-50
pubmed: 19901245
Genes Immun. 2012 Jan;13(1):14-20
pubmed: 21776012
Ann Neurol. 2011 Feb;69(2):292-302
pubmed: 21387374
Nat Genet. 2015 Oct;47(10):1107-1113
pubmed: 26343388
Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16955-16960
pubmed: 31375628
Nestle Nutr Workshop Ser Pediatr Program. 2009;63:151-9; discussion 159-62, 259-68
pubmed: 19346774
Neurology. 2014 Mar 11;82(10):865-72
pubmed: 24500647
Mult Scler. 2019 Feb;25(2):180-186
pubmed: 30251921
Ann Neurol. 2005 Dec;58(6):840-6
pubmed: 16283615
Neurology. 2018 Apr 3;90(14):e1191-e1199
pubmed: 29514944
Clin Chem. 2005 Oct;51(10):1845-53
pubmed: 16099939
Expert Rev Clin Immunol. 2011 May;7(3):287-94
pubmed: 21595595
Front Neurol. 2020 Jan 24;10:1368
pubmed: 32038456
Int J Obes Relat Metab Disord. 1995 Aug;19(8):570-2
pubmed: 7489028
J Leukoc Biol. 2008 Oct;84(4):893-9
pubmed: 18552206
Acta Neurol Scand. 2015;132(199):11-9
pubmed: 26046553
Exp Biol Med (Maywood). 2010 Dec;235(12):1412-24
pubmed: 21127339
Arch Neurol. 2006 Jun;63(6):839-44
pubmed: 16606758
Diabetes. 2007 Jan;56(1):16-23
pubmed: 17192460
PLoS One. 2010 Sep 01;5(9):
pubmed: 20824132
Eur J Neurol. 2015 Mar;22(3):578-e38
pubmed: 25530445
Autoimmun Rev. 2014 Sep;13(9):981-1000
pubmed: 25092612
Mult Scler. 2012 Sep;18(9):1334-6
pubmed: 22328681
BMJ. 2016 Feb 25;352:i969
pubmed: 26916049
Science. 2019 Sep 27;365(6460):
pubmed: 31604244
Arthritis Rheum. 2004 Oct;50(10):3085-92
pubmed: 15476204
PLoS Comput Biol. 2013;9(2):e1002877
pubmed: 23459081
Med Chem. 2018 Feb 6;14(2):129-143
pubmed: 28933265
Lancet. 2017 Dec 16;390(10113):2627-2642
pubmed: 29029897
Epidemiology. 2009 Jan;20(1):6-13
pubmed: 19234396