Microwave-Assisted Synthesis, Characterization and Modeling of CPO-27-Mg Metal-Organic Framework for Drug Delivery.
Acetaminophen
/ administration & dosage
Analgesics, Non-Narcotic
/ administration & dosage
Anti-Inflammatory Agents, Non-Steroidal
/ administration & dosage
Aspirin
/ administration & dosage
Drug Carriers
/ administration & dosage
Drug Delivery Systems
/ methods
Metal-Organic Frameworks
/ administration & dosage
Microwaves
Organometallic Compounds
/ administration & dosage
CPO-27
aspirin
drug delivery
metal-organic frameworks
microwave synthesis
paracetamol
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
15 Jan 2021
15 Jan 2021
Historique:
received:
14
11
2020
revised:
11
01
2021
accepted:
12
01
2021
entrez:
20
1
2021
pubmed:
21
1
2021
medline:
1
5
2021
Statut:
epublish
Résumé
The coordination polymer CPO-27-Mg was rapidly synthesized under microwave irradiation. This material exhibits a sufficiently high drug loading towards aspirin (~8% wt.) and paracetamol (~14% wt.). The binding of these two molecules with the inner surface of the metal-organic framework was studied employing the Gaussian and Plane Wave approach of the Density Functional Theory. The structure of CPO-27-Mg persists after the adsorption of aspirin or paracetamol and their desorption energies, being quite high, decrease under solvent conditions.
Identifiants
pubmed: 33467467
pii: molecules26020426
doi: 10.3390/molecules26020426
pmc: PMC7830474
pii:
doi:
Substances chimiques
Analgesics, Non-Narcotic
0
Anti-Inflammatory Agents, Non-Steroidal
0
Drug Carriers
0
Metal-Organic Frameworks
0
Organometallic Compounds
0
Acetaminophen
362O9ITL9D
Aspirin
R16CO5Y76E
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Science Foundation
ID : 20-63-46013
Organisme : Ministry of Science and Higher Education of the Russian Federation
ID : K2-2019-005
Organisme : Ministry of Science and Higher Education of the Russian Federation
ID : К4-2019-017
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