Development of a sensitive MEKC-LIF method for synthetic cathinones analysis.
Forensic analysis
MEKC-LIF
Neutral surfactant
Polyethylene glycol ether surfactants
Synthetic cathinones
Journal
Electrophoresis
ISSN: 1522-2683
Titre abrégé: Electrophoresis
Pays: Germany
ID NLM: 8204476
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
18
01
2021
received:
06
11
2020
accepted:
19
01
2021
pubmed:
23
1
2021
medline:
10
2
2022
entrez:
22
1
2021
Statut:
ppublish
Résumé
Synthetic cathinones are phenylalkylamine compounds related to natural cathinone from Catha edulis leaves. Due to their sympathomimetic effects comparable to common illicit drugs, these substances are mainly drugs of abuse and constitute the second most frequently seized group of new psychoactive substances. In order to ensure their regulation and to promote public health, reliable analytical tools are required to track these substances. In the present study, we developed a CE hyphenated to laser-induced fluorescence detection method to demonstrate its suitability to perform fast and cost-effective synthetic cathinones analysis. Fourteen compounds including isobaric compounds and position isomers were selected to encompass the large panel of chemical structures. To separate the FITC-labeled analytes (presenting the same negative charge and close mass to charge ratios), MEKC separation mode was selected. Method selectivity was not suitable using common surfactants. In this context, alkyl polyethylene glycol ether surfactants were successfully used as neutral surfactant to overcome this analytical challenge. The effect of surfactant nature on separation performances and migration behaviors of the analytes was also studied. Optimal BGE composition included 75 mM borate buffer at pH 9.3 and 0.4 mM of C12E10 surfactant. Final MEKC separation conditions were proposed to analyze a large panel of synthetic cathinones. This method helped to reach a sensitivity with LOD from 0.1 to 0.4 nM (pg/mL order).
Identifiants
pubmed: 33482013
doi: 10.1002/elps.202000331
doi:
Substances chimiques
Alkaloids
0
Illicit Drugs
0
Surface-Active Agents
0
cathinone
540EI4406J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1127-1134Informations de copyright
© 2021 Wiley-VCH GmbH.
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