Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin.

Carboxypeptidases / metabolism Carrier Proteins Cell Cycle Proteins / metabolism Cysteine Microtubules / metabolism Sesquiterpenes / pharmacology Tubulin / drug effects
detyrosination epoY parthenolide tubulin vasohibin

Journal

Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782

Informations de publication

Date de publication:
22 02 2021
Historique:
received: 24 08 2020
revised: 02 11 2020
accepted: 19 11 2020
pubmed: 23 1 2021
medline: 21 12 2021
entrez: 22 1 2021
Statut: ppublish

Résumé

Detyrosination of the α-tubulin C-terminal tail is a post-translational modification (PTM) of microtubules that is key for many biological processes.

Identifiants

DOI: 10.1016/j.cub.2020.11.055 PMID: 33482110 PMC: PMC7931505
pubmed: 33482110
pii: S0960-9822(20)31768-1
doi: 10.1016/j.cub.2020.11.055
pmc: PMC7931505
mid: NIHMS1665764
pii:
doi:

Substances chimiques

Carrier Proteins 0
Cell Cycle Proteins 0
Sesquiterpenes 0
Tubulin 0
parthenolide 2RDB26I5ZB
Carboxypeptidases EC 3.4.-
Cysteine K848JZ4886

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

900-907.e6

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM131744
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM086610
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM094231
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002240
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007315
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

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Auteurs

Takashi Hotta (T)

Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

Sarah E Haynes (SE)

Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

Teresa L Blasius (TL)

Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

Margo Gebbie (M)

Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

Emily L Eberhardt (EL)

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.

David Sept (D)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

Michael Cianfrocco (M)

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.

Kristen J Verhey (KJ)

Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

Alexey I Nesvizhskii (AI)

Department of Pathology, University of Michigan, Ann Arbor, MI, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.

Ryoma Ohi (R)

Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. Electronic address: oryoma@umich.edu.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Carboxypeptidases › Parthenolide Destabilizes Microtubules by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Parthenolide Destabilizes Microtubules by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Parthenolide Destabilizes Microtubules by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Parthenolide Destabilizes Microtubules by...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Microtubules › Parthenolide Destabilizes Microtubules by...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Parthenolide Destabilizes Microtubules by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Tubuline › Parthenolide Destabilizes Microtubules by...