David Sept

Publications (14)

Biophysical Mechanism of Allosteric Regulation of Actin Capping Protein.

bioRxiv : the preprint server for biology

Avec: Olivia L Mooren , Melissa D Stuchell-Brereton , Patrick McConnell , Chenbo Yan , Emily M Wilkerson , Dennis Goldfarb , John A Cooper , David Sept , Andrea Soranno

Motor Clustering Enhances Kinesin-driven Vesicle Transport.

bioRxiv : the preprint server for biology

Avec: Rui Jiang , Qingzhou Feng , Daguan Nong , You Jung Kang , David Sept , William O Hancock

EML2-S constitutes a new class of proteins that recognizes and regulates the dynamics of tyrosinated microtubules.

Current biology : CB

Avec: Takashi Hotta , Thomas S McAlear , Yang Yue , Takumi Higaki , Sarah E Haynes , Alexey I Nesvizhskii , David Sept , Kristen J Verhey , Susanne Bechstedt , Ryoma Ohi

Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.

bioRxiv : the preprint server for biology

Avec: Vipin Rawat , Patrick DeLear , Prarthana Prashanth , Mete Emir Ozgurses , Anteneh Tebeje , Philippa A Burns , Kelly O Conger , Christopher Solís , Yasir Hasnain , Anna Novikova , Jennifer E Endress , Paloma González-Sánchez , Wentao Dong , Greg Stephanopoulos , Gina M DeNicola , Isaac S Harris , David Sept , Frank M Mason , Jonathan L Coloff

Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms.

The Journal of cell biology

Avec: Breane G Budaitis , Shashank Jariwala , Lu Rao , Yang Yue , David Sept , Kristen J Verhey , Arne Gennerich

Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding.

Science advances

Avec: April L Solon , Zhenyu Tan , Katherine L Schutt , Lauren Jepsen , Sarah E Haynes , Alexey I Nesvizhskii , David Sept , Jason Stumpff , Ryoma Ohi , Michael A Cianfrocco

Biophysical Mechanism of Allosteric Regulation of Actin Capping Protein.

Journal of molecular biology

Avec: Olivia L Mooren , Melissa D Stuchell-Brereton , Patrick McConnell , Chenbo Yan , Emily M Wilkerson , Dennis Goldfarb , John A Cooper , David Sept , Andrea Soranno

Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin.

Current biology : CB

Avec: Takashi Hotta , Sarah E Haynes , Teresa L Blasius , Margo Gebbie , Emily L Eberhardt , David Sept , Michael Cianfrocco , Kristen J Verhey , Alexey I Nesvizhskii , Ryoma Ohi

Phase intensity nanoscope (PINE) opens long-time investigation windows of living matter.

Nature communications

Avec: Guangjie Cui , Yunbo Liu , Di Zu , Xintao Zhao , Zhijia Zhang , Do Young Kim , Pramith Senaratne , Aaron Fox , David Sept , Younggeun Park , Somin Eunice Lee

Entropic effects enable life at extreme temperatures.

Science advances

Avec: Young Hun Kim , Geoffray Leriche , Karthik Diraviyam , Takaoki Koyanagi , Kaifu Gao , David Onofrei , Joseph Patterson , Anirvan Guha , Nathan Gianneschi , Gregory P Holland , Michael K Gilson , Michael Mayer , David Sept , Jerry Yang

Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity.

eLife

Avec: Breane G Budaitis , Shashank Jariwala , Dana N Reinemann , Kristin I Schimert , Guido Scarabelli , Barry J Grant , David Sept , Matthew J Lang , Kristen J Verhey

Effects of Nucleotide and End-Dependent Actin Conformations on Polymerization.

Biophysical journal

Avec: Lauren Jepsen , David Sept

Clinical, genetic, and structural characterization of a novel TUBB4B tubulinopathy.

Molecular genetics and metabolism reports

Avec: Jason R McFadden , Christina Deanne P Tolete , Yan Huang , Ellen Macnamara , David Sept , Galina Nesterova , William A Gahl , Dan L Sackett , May Christine V Malicdan

Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.

JCI insight

Avec: Vipin Rawat , Patrick DeLear , Prarthana Prashanth , Mete Emir Ozgurses , Anteneh Tebeje , Philippa A Burns , Kelly O Conger , Christopher Solís , Yasir Hasnain , Anna Novikova , Jennifer E Endress , Paloma González-Sánchez , Wentao Dong , Greg Stephanopoulos , Gina M DeNicola , Isaac Harris , David Sept , Frank M Mason , Jonathan L Coloff

Réseau de co-auteurs

Kristen J Verhey 4 collaborations

Sarah E Haynes 3 collaborations

Alexey I Nesvizhskii 3 collaborations

Ryoma Ohi 3 collaborations

Olivia L Mooren 2 collaborations

Melissa D Stuchell-Brereton 2 collaborations

Patrick McConnell 2 collaborations

Chenbo Yan 2 collaborations

Emily M Wilkerson 2 collaborations

Dennis Goldfarb 2 collaborations

John A Cooper 2 collaborations

Andrea Soranno 2 collaborations

Takashi Hotta 2 collaborations

Yang Yue 2 collaborations

Vipin Rawat 2 collaborations

Patrick DeLear 2 collaborations

Prarthana Prashanth 2 collaborations

Mete Emir Ozgurses 2 collaborations

Anteneh Tebeje 2 collaborations

Philippa A Burns 2 collaborations

Kelly O Conger 2 collaborations

Christopher Solís 2 collaborations

Yasir Hasnain 2 collaborations

Anna Novikova 2 collaborations

Jennifer E Endress 2 collaborations

Paloma González-Sánchez 2 collaborations

Wentao Dong 2 collaborations

Greg Stephanopoulos 2 collaborations

Gina M DeNicola 2 collaborations

Frank M Mason 2 collaborations

Jonathan L Coloff 2 collaborations

Breane G Budaitis 2 collaborations

Shashank Jariwala 2 collaborations

Lauren Jepsen 2 collaborations

Rui Jiang 1 collaboration

Qingzhou Feng 1 collaboration

Daguan Nong 1 collaboration

You Jung Kang 1 collaboration

William O Hancock 1 collaboration

Thomas S McAlear 1 collaboration

Takumi Higaki 1 collaboration

Susanne Bechstedt 1 collaboration

Isaac S Harris 1 collaboration

Lu Rao 1 collaboration

Arne Gennerich 1 collaboration

April L Solon 1 collaboration

Zhenyu Tan 1 collaboration

Katherine L Schutt 1 collaboration

Jason Stumpff 1 collaboration

Michael A Cianfrocco 1 collaboration

Teresa L Blasius 1 collaboration

Margo Gebbie 1 collaboration

Emily L Eberhardt 1 collaboration

Michael Cianfrocco 1 collaboration

Guangjie Cui 1 collaboration

Yunbo Liu 1 collaboration

Di Zu 1 collaboration

Xintao Zhao 1 collaboration

Zhijia Zhang 1 collaboration

Do Young Kim 1 collaboration

Pramith Senaratne 1 collaboration

Aaron Fox 1 collaboration

Younggeun Park 1 collaboration

Somin Eunice Lee 1 collaboration

Young Hun Kim 1 collaboration

Geoffray Leriche 1 collaboration

Karthik Diraviyam 1 collaboration

Takaoki Koyanagi 1 collaboration

Kaifu Gao 1 collaboration

David Onofrei 1 collaboration

Joseph Patterson 1 collaboration

Anirvan Guha 1 collaboration

Nathan Gianneschi 1 collaboration

Gregory P Holland 1 collaboration

Michael K Gilson 1 collaboration

Michael Mayer 1 collaboration

Jerry Yang 1 collaboration

Dana N Reinemann 1 collaboration

Kristin I Schimert 1 collaboration

Guido Scarabelli 1 collaboration

Barry J Grant 1 collaboration

Matthew J Lang 1 collaboration

Jason R McFadden 1 collaboration

Christina Deanne P Tolete 1 collaboration

Yan Huang 1 collaboration

Ellen Macnamara 1 collaboration

Galina Nesterova 1 collaboration

William A Gahl 1 collaboration

Dan L Sackett 1 collaboration

May Christine V Malicdan 1 collaboration

Isaac Harris 1 collaboration