5′-UTR
COVID19-NMR
SARS-CoV-2
SL5a
Solution NMR spectroscopy
Journal
Biomolecular NMR assignments
ISSN: 1874-270X
Titre abrégé: Biomol NMR Assign
Pays: Netherlands
ID NLM: 101472371
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
09
12
2020
accepted:
08
01
2021
pubmed:
24
1
2021
medline:
7
4
2021
entrez:
23
1
2021
Statut:
ppublish
Résumé
The SARS-CoV-2 (SCoV-2) virus is the causative agent of the ongoing COVID-19 pandemic. It contains a positive sense single-stranded RNA genome and belongs to the genus of Betacoronaviruses. The 5'- and 3'-genomic ends of the 30 kb SCoV-2 genome are potential antiviral drug targets. Major parts of these sequences are highly conserved among Betacoronaviruses and contain cis-acting RNA elements that affect RNA translation and replication. The 31 nucleotide (nt) long highly conserved stem-loop 5a (SL5a) is located within the 5'-untranslated region (5'-UTR) important for viral replication. SL5a features a U-rich asymmetric bulge and is capped with a 5'-UUUCGU-3' hexaloop, which is also found in stem-loop 5b (SL5b). We herein report the extensive
Identifiants
pubmed: 33484403
doi: 10.1007/s12104-021-10007-w
pii: 10.1007/s12104-021-10007-w
pmc: PMC7822759
doi:
Substances chimiques
5' Untranslated Regions
0
Carbon Isotopes
0
Nitrogen Isotopes
0
Nitrogen-15
0
Hydrogen
7YNJ3PO35Z
Coronavirus Papain-Like Proteases
EC 3.4.22.2
papain-like protease, SARS-CoV-2
EC 3.4.22.2
Carbon-13
FDJ0A8596D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
203-211Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : CRC902
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK 1986
Organisme : Deutsche Forschungsgemeinschaft
ID : Infrastructure program: 277478796, 277479031, 392682309, 452632086, 70653611
Organisme : Hessisches Ministerium für Wissenschaft und Kunst
ID : BMRZ
Organisme : Hessisches Ministerium für Wissenschaft und Kunst
ID : IWB-EFRE-programme 20007375
Organisme : Karolinska Institutet
ID : Start-Up funds
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