Structural insights and molecular dynamics into the inhibitory mechanism of a Kunitz-type trypsin inhibitor from

Dose-Response Relationship, Drug Molecular Dynamics Simulation Molecular Structure Plant Extracts / chemistry Seeds / chemistry Structure-Activity Relationship Tamarindus / chemistry Trypsin / metabolism Trypsin Inhibitors / chemistry
Tamarind antitryptic computational methods homology modelling protein-protein interaction

Journal

Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203

Informations de publication

Date de publication:
Dec 2021
Historique:
entrez: 25 1 2021
pubmed: 26 1 2021
medline: 25 6 2021
Statut: ppublish

Résumé

Trypsin inhibitors from tamarind seed have been studied

Identifiants

DOI: 10.1080/14756366.2021.1876686 PMID: 33491503 PMC: PMC7875565
pubmed: 33491503
doi: 10.1080/14756366.2021.1876686
pmc: PMC7875565
doi:

Substances chimiques

Plant Extracts 0
Trypsin Inhibitors 0
Trypsin EC 3.4.21.4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

480-490

Références

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Auteurs

Amanda Fernandes de Medeiros (AF)

Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
ORCID: 0000-0002-1354-0116

Beatriz Blenda Pinheiro de Souza (BBP)

Postgraduate Biological Molecular, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.
Laboratory of Mass Spectometry-LEM, Embrapa Genetic Resources and Biotechnology, Brasília, Brazil.
ORCID: 0000-0002-6793-6386

Lucas Pinheiro Coutinho (LP)

Chemistry Course, Science Center, Federal University of Ceará, Fortaleza, Brazil.
ORCID: 0000-0001-9591-5593

Aline Melro Murad (AM)

Laboratory of Mass Spectometry-LEM, Embrapa Genetic Resources and Biotechnology, Brasília, Brazil.
ORCID: 0000-0003-3222-4001

Paula Ivani Medeiros Dos Santos (PIM)

Federal Institute of Education, Science and Technology of Rio Grande do Norte, Brazil.
ORCID: 0000-0003-2955-8174

Norberto de Kássio Vieira Monteiro (NKV)

Analytical Chemistry and physical Chemistry Department, Science Center, Federal University of Ceará, Fortaleza, Brazil.
ORCID: 0000-0002-5847-5733

Elizeu Antunes Dos Santos (EAD)

Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
Department of Biochemistry, Biosciences Center, Federal University of Rio Grande, Natal, Brazil.
Tropical Medicine Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
ORCID: 0000-0003-4372-2161

Bruna Leal Lima Maciel (BLL)

Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
ORCID: 0000-0002-0724-1961

Ana Heloneida de Araújo Morais (AH)

Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
ORCID: 0000-0002-6460-911X

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Structural insights and molecular dynamics...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Structural insights and molecular dynamics...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Structural insights and molecular dynamics...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Structural insights and molecular dynamics...
questionsmedicales.fr › Aliments et boissons › Aliments › Graines › Structural insights and molecular dynamics...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Structural insights and molecular dynamics...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Fabaceae › Tamarindus › Structural insights and molecular dynamics...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Trypsine › Structural insights and molecular dynamics...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéases › Inhibiteurs de la sérine protéinase › Inhibiteurs trypsiques › Structural insights and molecular dynamics...