Deuterium Metabolic Imaging of the Healthy and Diseased Brain.
MR spectroscopy
MRI
brain metabolism
deuterium
stroke
tumor
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
15 10 2021
15 10 2021
Historique:
received:
17
11
2020
revised:
12
01
2021
accepted:
13
01
2021
pubmed:
26
1
2021
medline:
11
11
2021
entrez:
25
1
2021
Statut:
ppublish
Résumé
Altered brain metabolism contributes to pathophysiology in cerebrovascular and neurodegenerative diseases such as stroke and Alzheimer's disease. Current clinical tools to study brain metabolism rely on positron emission tomography (PET) requiring specific hardware and radiotracers, or magnetic resonance spectroscopy (MRS) involving technical complexity. In this review we highlight deuterium metabolic imaging (DMI) as a novel translational technique for assessment of brain metabolism, with examples from brain tumor and stroke studies. DMI is an MRS-based method that enables detection of deuterated substrates, such as glucose, and their metabolic products, such as lactate, glutamate and glutamine. It provides additional detail of downstream metabolites compared to analogous approaches like fluorodeoxyglucose (FDG)-PET, and can be implemented and executed on clinical and preclinical MR systems. We foresee that DMI, with future improvements in spatial and temporal resolutions, holds promise to become a valuable MR imaging (MRI) method for non-invasive mapping of glucose uptake and its downstream metabolites in healthy and diseased brain.
Identifiants
pubmed: 33493618
pii: S0306-4522(21)00030-0
doi: 10.1016/j.neuroscience.2021.01.023
pmc: PMC9846473
mid: NIHMS1864516
pii:
doi:
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
Deuterium
AR09D82C7G
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
94-99Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB025840
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH095104
Pays : United States
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
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