Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer's Disease.
Adenosine Triphosphate
/ biosynthesis
Alzheimer Disease
/ metabolism
Animals
Calcium Signaling
Cell Respiration
Citric Acid Cycle
Cytosol
/ metabolism
Endoplasmic Reticulum
/ metabolism
Glycolysis
Membrane Potential, Mitochondrial
Mice, Inbred C57BL
Mice, Knockout
Mitochondria
/ metabolism
Neurons
/ metabolism
Oxidative Phosphorylation
Phenotype
Presenilin-2
/ deficiency
Alzheimer′s disease
Ca2+ signaling
PS2–/–
bioenergetics
mitochondria
mitochondrial membrane potential
neuronal hyperexcitability
oxygen consumption rate
presenilin 2
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
21 01 2021
21 01 2021
Historique:
received:
15
12
2020
revised:
17
01
2021
accepted:
18
01
2021
entrez:
26
1
2021
pubmed:
27
1
2021
medline:
13
10
2021
Statut:
epublish
Résumé
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder in which learning, memory and cognitive functions decline progressively. Familial forms of AD (FAD) are caused by mutations in amyloid precursor protein (
Identifiants
pubmed: 33494218
pii: cells10020204
doi: 10.3390/cells10020204
pmc: PMC7909802
pii:
doi:
Substances chimiques
Presenilin-2
0
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the Italian Ministry of University and Scientific Research
ID : PRIN2017XA5J5N
Organisme : EU Joint Programme in Neurodegenerative Disease, 2015-2018
ID : grant CeBioND
Organisme : UNIPD Funds for Research Equipment
ID : UNIPD Funds for Research Equipment
Organisme : Fondazione Cassa di Risparmio di Padova e Rovigo (CARIPARO Foundation) Excellence project 2017 (2018/113
ID : Fondazione Cassa di Risparmio di Padova e Rovigo (CARIPARO Foundation) Excellence project 2017 (2018/113
Organisme : Veneto Region ([RISIB Project])
ID : Veneto Region ([RISIB Project]),
Organisme : Consiglio Nazionale delle Ricerche (CNR) Special Project Aging
ID : Consiglio Nazionale delle Ricerche (CNR) Special Project Aging
Organisme : Euro Bioimaging Project Roadmap/ESFRI from European Commission
ID : Euro Bioimaging Project Roadmap/ESFRI from European Commission
Organisme : telethon Italy
ID : GGP16029A
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