Trajectories of Left Ventricular Ejection Fraction After Acute Decompensation for Systolic Heart Failure: Concomitant Echocardiographic and Systemic Changes, Predictors, and Impact on Clinical Outcomes.


Journal

Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524

Informations de publication

Date de publication:
02 02 2021
Historique:
pubmed: 27 1 2021
medline: 14 10 2021
entrez: 26 1 2021
Statut: ppublish

Résumé

Background Prospective longitudinal follow-up of left ventricular ejection fraction (LVEF) trajectories after acute cardiac decompensation of heart failure is lacking. We investigated changes in LVEF and covariates at 6-months' follow-up in patients with a predischarge LVEF ≤40%, and determined predictors and prognostic implications of LVEF changes through 18-months' follow-up. Methods and Results Interdisciplinary Network Heart Failure program participants (n=633) were categorized into subgroups based on LVEF at 6-months' follow-up: normalized LVEF (>50%; heart failure with normalized ejection fraction, n=147); midrange LVEF (41%-50%; heart failure with midrange ejection fraction, n=195), or persistently reduced LVEF (≤40%; heart failure with persistently reduced LVEF , n=291). All received guideline-directed medical therapies. At 6-months' follow-up, compared with patients with heart failure with persistently reduced LVEF, heart failure with normalized LVEF or heart failure with midrange LVEF subgroups showed greater reductions in LV end-diastolic/end-systolic diameters (both

Identifiants

pubmed: 33496189
doi: 10.1161/JAHA.120.017822
pmc: PMC7955416
doi:

Banques de données

ISRCTN
['ISRCTN23325295']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e017822

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Auteurs

Judith Albert (J)

Department of Internal Medicine I Cardiology University Hospital Würzburg Würzburg Germany.
Comprehensive Heart Failure Centre University and University Hospital Würzburg Germany.

Susanne Lezius (S)

Medical Center Hamburg-EppendorfInstitute of Medical Biometry and Epidemiology Hamburg Germany.

Stefan Störk (S)

Department of Internal Medicine I Cardiology University Hospital Würzburg Würzburg Germany.
Comprehensive Heart Failure Centre University and University Hospital Würzburg Germany.

Caroline Morbach (C)

Department of Internal Medicine I Cardiology University Hospital Würzburg Würzburg Germany.
Comprehensive Heart Failure Centre University and University Hospital Würzburg Germany.

Gülmisal Güder (G)

Department of Internal Medicine I Cardiology University Hospital Würzburg Würzburg Germany.
Comprehensive Heart Failure Centre University and University Hospital Würzburg Germany.

Stefan Frantz (S)

Department of Internal Medicine I Cardiology University Hospital Würzburg Würzburg Germany.
Comprehensive Heart Failure Centre University and University Hospital Würzburg Germany.

Karl Wegscheider (K)

Medical Center Hamburg-EppendorfInstitute of Medical Biometry and Epidemiology Hamburg Germany.

Georg Ertl (G)

Comprehensive Heart Failure Centre University and University Hospital Würzburg Germany.

Christiane E Angermann (CE)

Comprehensive Heart Failure Centre University and University Hospital Würzburg Germany.

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