Reward motivation and cognitive flexibility in tau null-mutation mice.

Alzheimer Disease / psychology Animals Cognition / physiology Conditioning, Operant / physiology Disease Models, Animal Female Frontotemporal Dementia / psychology Learning / physiology Loss of Function Mutation Male Mice, Knockout Motivation / genetics Reward Tauopathies / psychology tau Proteins / genetics
Operant conditioning Progressive ratio Reversal learning Reward Reward sensitivity Tau knockout mice

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
04 2021
Historique:
received: 25 05 2020
revised: 05 11 2020
accepted: 15 12 2020
pubmed: 2 2 2021
medline: 9 11 2021
entrez: 1 2 2021
Statut: ppublish

Résumé

The reduction of tau or hyperphosphorylated tau (p-tau) has been proposed as a therapeutic strategy for Alzheimer's disease (AD) and frontotemporal dementia (FTD). Cognitive decline and sleep-wake dysregulation seen in AD and FTD patients are mimicked in transgenic and null-mutation mouse models of tauopathy. Alterations in the reward system are additional symptoms of AD and FTD. However, the role of tau in reward processes is not well understood. The present study aimed to examine reward and reward-motivated cognitive processes in male and female tau knockout (tau

Identifiants

DOI: 10.1016/j.neurobiolaging.2020.12.017 PMID: 33524848
pubmed: 33524848
pii: S0197-4580(20)30428-0
doi: 10.1016/j.neurobiolaging.2020.12.017
pii:
doi:

Substances chimiques

tau Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106-117

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Sara Oberrauch (S)

The Florey Institute of Neuroscience and Mental Health, Parkville Campus, University of Melbourne, Parkville, Australia; Department of Pharmacology & Therapeutics, School of Medicine, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Jeremy A Metha (JA)

The Florey Institute of Neuroscience and Mental Health, Parkville Campus, University of Melbourne, Parkville, Australia; Department of Pharmacology & Therapeutics, School of Medicine, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia; Department of Finance, Brain, Mind & Markets Laboratory, The University of Melbourne, Melbourne, Victoria, Australia.

Maddison L Brian (ML)

The Florey Institute of Neuroscience and Mental Health, Parkville Campus, University of Melbourne, Parkville, Australia; Department of Pharmacology & Therapeutics, School of Medicine, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Samuel A Barnes (SA)

Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA.

Travis J Featherby (TJ)

The Florey Institute of Neuroscience and Mental Health, Parkville Campus, University of Melbourne, Parkville, Australia.

Andrew J Lawrence (AJ)

The Florey Institute of Neuroscience and Mental Health, Parkville Campus, University of Melbourne, Parkville, Australia.

Daniel Hoyer (D)

The Florey Institute of Neuroscience and Mental Health, Parkville Campus, University of Melbourne, Parkville, Australia; Department of Pharmacology & Therapeutics, School of Medicine, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.

Carsten Murawski (C)

Department of Finance, Brain, Mind & Markets Laboratory, The University of Melbourne, Melbourne, Victoria, Australia.

Laura H Jacobson (LH)

The Florey Institute of Neuroscience and Mental Health, Parkville Campus, University of Melbourne, Parkville, Australia; Department of Pharmacology & Therapeutics, School of Medicine, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia; Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health and The University of Melbourne, Victoria, Australia. Electronic address: laura.jacobson@florey.edu.au.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Reward motivation and cognitive flexibility in...
questionsmedicales.fr › Eucaryotes › Animaux › Reward motivation and cognitive flexibility in...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Reward motivation and cognitive flexibility in...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Conditionnement (psychologie) › Conditionnement opérant › Reward motivation and cognitive flexibility in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Reward motivation and cognitive flexibility in...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Dégénérescence lobaire frontotemporale › Démence frontotemporale › Reward motivation and cognitive flexibility in...
questionsmedicales.fr › Phénomènes psychologiques › Psychologie appliquée › Apprentissage › Reward motivation and cognitive flexibility in...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation perte de fonction › Reward motivation and cognitive flexibility in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Reward motivation and cognitive flexibility in...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Personnalité › Intelligence › Intelligence émotionnelle › Motivation › Reward motivation and cognitive flexibility in...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Renforcement (psychologie) › Récompense › Reward motivation and cognitive flexibility in...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Tauopathies › Reward motivation and cognitive flexibility in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Reward motivation and cognitive flexibility in...