Modulation of α
Aged
Antigens, Neoplasm
/ genetics
Biomarkers
Chromatography, Liquid
Disease Susceptibility
Female
Humans
Immunohistochemistry
Immunophenotyping
Inflammation Mediators
/ metabolism
Integrins
/ genetics
Male
Middle Aged
Osteoarthritis
/ complications
Peptides
/ chemistry
Protein Binding
Protein Interaction Domains and Motifs
Proteomics
/ methods
Synoviocytes
/ metabolism
Synovitis
/ blood
Tandem Mass Spectrometry
Transforming Growth Factor beta1
/ metabolism
Vitronectin
/ chemistry
Journal
Experimental & molecular medicine
ISSN: 2092-6413
Titre abrégé: Exp Mol Med
Pays: United States
ID NLM: 9607880
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
07
07
2020
accepted:
16
11
2020
revised:
16
11
2020
pubmed:
3
2
2021
medline:
19
2
2022
entrez:
2
2
2021
Statut:
ppublish
Résumé
Osteoarthritis is characterized by structural alteration of joints. Fibrosis of the synovial tissue is often detected and considered one of the main causes of joint stiffness and pain. In our earlier proteomic study, increased levels of vitronectin (VTN) fragment (amino acids 381-397) were observed in the serum of osteoarthritis patients. In this work, the affinity of this fragment for integrins and its putative role in TGF-β1 activation were investigated. A competition study determined the interaction of VTN
Identifiants
pubmed: 33526813
doi: 10.1038/s12276-021-00558-2
pii: 10.1038/s12276-021-00558-2
pmc: PMC8080589
doi:
Substances chimiques
Antigens, Neoplasm
0
Biomarkers
0
Inflammation Mediators
0
Integrins
0
Peptides
0
Transforming Growth Factor beta1
0
Vitronectin
0
integrin alphavbeta6
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
210-222Références
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