Clinical and whole genome characterization of SARS-CoV-2 in India.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
08
2020
accepted:
14
01
2021
entrez:
2
2
2021
pubmed:
3
2
2021
medline:
12
2
2021
Statut:
epublish
Résumé
We report clinical profile of hundred and nine patients with SARS CoV-2 infection, and whole genome sequences (WGS) of seven virus isolates from the first reported cases in India, with various international travel histories. Comorbidities such as diabetes, hypertension, and cardiovascular disease were frequently associated with severity of the disease. WBC and neutrophil counts showed an increase, while lymphocyte counts decreased in patients with severe infection suggesting a possible neutrophil mediated organ damage, while immune activity may be diminished with decrease in lymphocytes leading to disease severity. Increase in SGOT, SGPT and blood urea suggests the functional deficiencies of liver, heart, and kidney in patients who succumbed to the disease when compared to the group of recovered patients. The WGS analysis showed that these isolates were classified into two clades: I/A3i, and A2a (four according to GISAID: O, L, GR, and GH). Further, WGS phylogeny and travel history together indicate possible transmission from Middle East and Europe. Three S protein variants: Wuhan reference, D614G, and Y28H were identified predicted to possess different binding affinities to host ACE2.
Identifiants
pubmed: 33529260
doi: 10.1371/journal.pone.0246173
pii: PONE-D-20-25334
pmc: PMC7853523
doi:
Substances chimiques
RNA, Viral
0
Spike Glycoprotein, Coronavirus
0
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0246173Subventions
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests
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