Comparison of regional brain deficit patterns in common psychiatric and neurological disorders as revealed by big data.

Aged Alzheimer Disease / diagnostic imaging Big Data Brain / diagnostic imaging Depressive Disorder, Major / diagnostic imaging Female Humans Magnetic Resonance Imaging Male Middle Aged
Big data DTI ENIGMA Meta-analysis RVI Structural deficit patterns

Journal

NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070

Informations de publication

Date de publication:
2021
Historique:
received: 23 07 2020
revised: 08 12 2020
accepted: 16 01 2021
pubmed: 3 2 2021
medline: 29 6 2021
entrez: 2 2 2021
Statut: ppublish

Résumé

Neurological and psychiatric illnesses are associated with regional brain deficit patterns that bear unique signatures and capture illness-specific characteristics. The Regional Vulnerability Index (RVI) was developed toquantify brain similarity by comparing individual white matter microstructure, cortical gray matter thickness and subcortical gray matter structural volume measures with neuroanatomical deficit patterns derived from large-scale meta-analytic studies. We tested the specificity of the RVI approach for major depressive disorder (MDD) and Alzheimer's disease (AD) in a large epidemiological sample of UK Biobank (UKBB) participants (N = 19,393; 9138 M/10,255F; age = 64.8 ± 7.4 years). Compared to controls free of neuropsychiatric disorders, participants with MDD (N = 2,248; 805 M/1443F; age = 63.4 ± 7.4) had significantly higher RVI-MDD values (t = 5.6, p = 1·10

Identifiants

DOI: 10.1016/j.nicl.2021.102574 PMID: 33530016 PMC: PMC7851406
pubmed: 33530016
pii: S2213-1582(21)00018-8
doi: 10.1016/j.nicl.2021.102574
pmc: PMC7851406
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102574

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH116948
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015922
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH123163
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117601
Pays : United States
Organisme : NIH HHS
ID : S10 OD023696
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH108148
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH112180
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB015611
Pays : United States

Informations de copyright

Copyright © 2021. Published by Elsevier Inc.

Auteurs

Peter Kochunov (P)

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: pkochunov@som.umaryland.edu.

Meghann C Ryan (MC)

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: MCRyan@som.umaryland.edu.

Qifan Yang (Q)

Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA. Electronic address: qifan.yang@usc.edu.

Kathryn S Hatch (KS)

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: KHatch@som.umaryland.edu.

Alyssa Zhu (A)

Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA. Electronic address: alyssa.zhu@ini.usc.edu.

Sophia I Thomopoulos (SI)

Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA. Electronic address: sthomopo@usc.edu.

Neda Jahanshad (N)

Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA. Electronic address: neda.jahanshad@usc.edu.

Lianne Schmaal (L)

Orygen, Parkville, Australia; Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia. Electronic address: lianne.schmaal@unimelb.edu.au.

Paul M Thompson (PM)

Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA. Electronic address: pthomp@usc.edu.

Shuo Chen (S)

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: ShuoChen@som.umaryland.edu.

Xiaoming Du (X)

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: XDu@som.umaryland.edu.

Bhim M Adhikari (BM)

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: BAdhikari@som.umaryland.edu.

Heather Bruce (H)

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: HBruce@som.umaryland.edu.

Stephanie Hare (S)

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: Stephanie.Hare@som.umaryland.edu.

Eric L Goldwaser (EL)

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: EGoldwaser@som.umaryland.edu.

Mark D Kvarta (MD)

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: Mark.Kvarta@som.umaryland.edu.

Thomas E Nichols (TE)

Nuffield Department of Population Health of the University of Oxford, Oxford, United Kingdom. Electronic address: thomas.nichols@bdi.ox.ac.uk.

L Elliot Hong (LE)

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: Ehong@som.umaryland.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Comparison of regional brain deficit patterns...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Comparison of regional brain deficit patterns...
questionsmedicales.fr › Sciences de l'information › Informatique › Informatique médicale › Applications de l'informatique médicale › Systèmes d'information › Mégadonnées › Comparison of regional brain deficit patterns...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Comparison of regional brain deficit patterns...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Comparison of regional brain deficit patterns...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Comparison of regional brain deficit patterns...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Comparison of regional brain deficit patterns...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Comparison of regional brain deficit patterns...