5-HT/GABA interaction in epilepsy.
5-HT
5-HT receptors
GABA
GABA(A) receptors
epilepsy
Journal
Progress in brain research
ISSN: 1875-7855
Titre abrégé: Prog Brain Res
Pays: Netherlands
ID NLM: 0376441
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
5
2
2021
pubmed:
6
2
2021
medline:
25
11
2021
Statut:
ppublish
Résumé
Epilepsy is a neurological condition characterized by synchronous neuronal oscillations (seizures) in the electroencephalogram. Seizures are classified in focal or generalized (depending on the brain territory interested during seizures), and in convulsive and/or not convulsive (depending on the presence or not of involuntary movements). The current pharmacological treatments are mainly based on GABA modulation although different neurotransmitters are also involved in epilepsy, including serotonin. However despite much extensive progress in the understanding of epilepsy mechanisms, still, a percentage of people with epilepsy are pharmaco-resistant calling for the need for new therapeutic targets. Here we review preclinical and human evidence showing that serotonin modulates epilepsy that this likely happens via a major modulation/interaction with GABA.
Identifiants
pubmed: 33541679
pii: S0079-6123(21)00008-X
doi: 10.1016/bs.pbr.2021.01.008
pii:
doi:
Substances chimiques
Neurotransmitter Agents
0
Serotonin
333DO1RDJY
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
265-286Informations de copyright
© 2021 Elsevier B.V. All rights reserved.