Polymorphisms rs2745557 in PTGS2 and rs2075797 in PTGER2 are associated with the risk of chronic obstructive pulmonary disease development in a Tunisian cohort.
Aged
Alleles
Case-Control Studies
Cohort Studies
Cyclooxygenase 2
/ genetics
Cytokines
/ blood
Dinoprostone
/ blood
Female
Gene Frequency
Genetic Predisposition to Disease
/ genetics
Humans
Male
Middle Aged
Patient Acuity
Polymorphism, Single Nucleotide
Prostaglandin D2
/ blood
Pulmonary Disease, Chronic Obstructive
/ blood
Receptors, Prostaglandin E, EP2 Subtype
/ genetics
Receptors, Prostaglandin E, EP4 Subtype
/ genetics
Risk Factors
Tunisia
/ epidemiology
Chronic obstructive pulmonary disease
Cyclooxygenase-2
Cytokines
Genetic polymorphisms
Oxidative stress markers
PTGER
Prostaglandins
Journal
Prostaglandins, leukotrienes, and essential fatty acids
ISSN: 1532-2823
Titre abrégé: Prostaglandins Leukot Essent Fatty Acids
Pays: Scotland
ID NLM: 8802730
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
01
10
2020
revised:
25
01
2021
accepted:
27
01
2021
pubmed:
6
2
2021
medline:
21
12
2021
entrez:
5
2
2021
Statut:
ppublish
Résumé
We hypothesized that polymorphisms of genes involved in the prostaglandin pathway could be associated with COPD. In this study we explored the involvement of genetic polymorphisms in PTGS2, PTGER2 and PTGER4 genes in the development and severity of COPD and their effects on plasma concentrations of inflammatory/oxidative stress markers. We identified genotypes of PTGS2, PTGER2 and PTGER4 SNPs in a Tunisian cohort including COPD patients (n = 138) and control subjects (n = 216) using PCR-RFLP and PCR TaqMan. Pulmonary function (FEV1 and FVC) were assessed by plethsmography. PGE
Identifiants
pubmed: 33545665
pii: S0952-3278(21)00015-6
doi: 10.1016/j.plefa.2021.102252
pii:
doi:
Substances chimiques
Cytokines
0
PTGER2 protein, human
0
PTGER4 protein, human
0
Receptors, Prostaglandin E, EP2 Subtype
0
Receptors, Prostaglandin E, EP4 Subtype
0
Cyclooxygenase 2
EC 1.14.99.1
PTGS2 protein, human
EC 1.14.99.1
Dinoprostone
K7Q1JQR04M
Prostaglandin D2
RXY07S6CZ2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102252Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.