Human Leukocyte Antigen Class II associations in late-onset Myasthenia Gravis.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
16
11
2020
revised:
26
12
2020
accepted:
13
01
2021
pubmed:
7
2
2021
medline:
3
11
2021
entrez:
6
2
2021
Statut:
ppublish
Résumé
Genetic factors predisposing to late-onset myasthenia gravis (LOMG) have not been clearly defined yet. However, genome-wide association studies identified Human Leukocyte Antigen (HLA) Class II alleles as a hotspot in this disease subtype. The aim of this study was to analyze the correlations of HLA Class II alleles with clinical data and titin antibodies in this patient subgroup. This study consecutively enrolled anti-acetylcholine receptor antibody-positive, non-thymoma patients with generalized LOMG. All patients were of Italian ancestry. HLA-DRB1 and -DQB1 genotyping and serum titin antibody testing were performed in this population. A total of 107 patients (females: 28/107, 26.2%; median age of onset: 68 years, range: 50-92) were included. We found a positive association with HLA-DRB1*07 (P = 1.1 × 10 In our study, we identified the HLA DRB1*07-DQB1*02 haplotype as a predisposing factor for the development of generalized LOMG in the Italian population.
Identifiants
pubmed: 33547763
doi: 10.1002/acn3.51309
pmc: PMC7951107
doi:
Substances chimiques
Autoantibodies
0
Connectin
0
HLA-DQ beta-Chains
0
HLA-DQB1 antigen
0
HLA-DRB1 Chains
0
HLA-DRB1*07 antigen
0
Receptors, Cholinergic
0
TTN protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
656-665Informations de copyright
© 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
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