Association of Bronchopulmonary Dysplasia and Right Ventricular Systolic Function in Young Adults Born Preterm.
Adolescent
Adult
Bronchopulmonary Dysplasia
/ complications
Echocardiography, Doppler
Female
Heart Ventricles
/ diagnostic imaging
Humans
Incidence
Infant, Newborn
Infant, Premature
Male
Quebec
/ epidemiology
Risk Assessment
/ methods
Systole
Ventricular Dysfunction, Right
/ epidemiology
Ventricular Function, Right
/ physiology
Young Adult
TAPSE
bronchopulmonary dysplasia
pediatric cardiology
preterm birth
right ventricle
Journal
Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
11
08
2020
revised:
05
12
2020
accepted:
16
01
2021
pubmed:
8
2
2021
medline:
26
11
2021
entrez:
7
2
2021
Statut:
ppublish
Résumé
Adults born preterm are at a higher risk of cardiopulmonary disease and premature death. Preterm birth is associated with abnormalities in right ventricular (RV) structure and function, but the impact of bronchopulmonary dysplasia (BPD), a common complication of extremely preterm birth, on these parameters remains unknown. Are preterm birth and BPD associated with alterations in RV structure and function in early adulthood? Echocardiographic and spirometry data were obtained from the Health of Adults Born Preterm Investigation (HAPI). RV structure and performance were evaluated by using echocardiography, and respiratory function was assessed by using spirometry. The study comprised 86 young adults born preterm before 30 weeks of gestation, including 28 with moderate to severe BPD, and 85 adults of the same age born full term. Individuals were assessed at a mean age of 23 years. RV systolic function was altered in the preterm group, with lower tricuspid annular plane systolic excursion and lower RV s' and RV outflow tract velocity time integral values, especially in those born preterm with BPD. Nine (36%) participants born preterm with BPD, six (13%) participants born preterm without BPD, and six (8%) participants born full term had a tricuspid annular plane systolic excursion value < 16 mm, a marker of RV systolic dysfunction (P value for the comparison between preterm no BPD and BPD, .032). No difference was found in RV diastolic function or estimates of pulmonary artery pressure between groups. Although respiratory function was altered in those born preterm, and more so in the case of BPD, no association was observed between spirometry indices of respiratory function and RV systolic function. Preterm birth is associated in adulthood with alterations in RV systolic function, which are more pronounced in the case of BPD. ClinicalTrials.gov; No.: NCT03261609; URL: www.clinicaltrials.gov.
Sections du résumé
BACKGROUND
Adults born preterm are at a higher risk of cardiopulmonary disease and premature death. Preterm birth is associated with abnormalities in right ventricular (RV) structure and function, but the impact of bronchopulmonary dysplasia (BPD), a common complication of extremely preterm birth, on these parameters remains unknown.
RESEARCH QUESTION
Are preterm birth and BPD associated with alterations in RV structure and function in early adulthood?
STUDY DESIGN AND METHODS
Echocardiographic and spirometry data were obtained from the Health of Adults Born Preterm Investigation (HAPI). RV structure and performance were evaluated by using echocardiography, and respiratory function was assessed by using spirometry.
RESULTS
The study comprised 86 young adults born preterm before 30 weeks of gestation, including 28 with moderate to severe BPD, and 85 adults of the same age born full term. Individuals were assessed at a mean age of 23 years. RV systolic function was altered in the preterm group, with lower tricuspid annular plane systolic excursion and lower RV s' and RV outflow tract velocity time integral values, especially in those born preterm with BPD. Nine (36%) participants born preterm with BPD, six (13%) participants born preterm without BPD, and six (8%) participants born full term had a tricuspid annular plane systolic excursion value < 16 mm, a marker of RV systolic dysfunction (P value for the comparison between preterm no BPD and BPD, .032). No difference was found in RV diastolic function or estimates of pulmonary artery pressure between groups. Although respiratory function was altered in those born preterm, and more so in the case of BPD, no association was observed between spirometry indices of respiratory function and RV systolic function.
INTERPRETATION
Preterm birth is associated in adulthood with alterations in RV systolic function, which are more pronounced in the case of BPD.
CLINICAL TRIAL REGISTRATION
ClinicalTrials.gov; No.: NCT03261609; URL: www.clinicaltrials.gov.
Identifiants
pubmed: 33549599
pii: S0012-3692(21)00253-1
doi: 10.1016/j.chest.2021.01.079
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT03261609']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
287-296Subventions
Organisme : CIHR
ID : MOP-133572
Pays : Canada
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.