CD8+ T-Cell Repertoire in Human Leukocyte Antigen Class I-Mismatched Alloreactive Immune Response.
CD8-Positive T-Lymphocytes
/ immunology
Hematopoietic Stem Cell Transplantation
Histocompatibility Antigens Class I
/ immunology
Humans
Interferon-beta
/ immunology
Lymphocyte Culture Test, Mixed
Transplantation, Homologous
Tumor Necrosis Factor Receptor Superfamily, Member 9
/ immunology
Tumor Necrosis Factor-alpha
/ immunology
T-cell alloreactivity
T-cell receptor
T-cell repertoire
hematopoietic stem cell transplantation (HSCT)
human leukocyte antigen (HLA)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
07
2020
accepted:
26
11
2020
entrez:
8
2
2021
pubmed:
9
2
2021
medline:
16
7
2021
Statut:
epublish
Résumé
In transplantation, direct allorecognition is a complex interplay between T-cell receptors (TCR) and HLA molecules and their bound peptides expressed on antigen-presenting cells. In analogy to HLA mismatched hematopoietic stem cell transplantation (HSCT), the TCR CDR3β repertoires of alloreactive cytotoxic CD8
Identifiants
pubmed: 33552048
doi: 10.3389/fimmu.2020.588741
pmc: PMC7856301
doi:
Substances chimiques
Histocompatibility Antigens Class I
0
Tumor Necrosis Factor Receptor Superfamily, Member 9
0
Tumor Necrosis Factor-alpha
0
Interferon-beta
77238-31-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
588741Informations de copyright
Copyright © 2021 Bettens, Calderin Sollet, Buhler and Villard.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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