To breathe or not to breathe: Understanding how oxygen sensing contributes to age-related phenotypes.

Cellular Senescence Longevity Oxygen Phenotype Reactive Oxygen Species
Ageing Aging Hypoxia Oxygen Pathology Senescence

Journal

Ageing research reviews
ISSN: 1872-9649
Titre abrégé: Ageing Res Rev
Pays: England
ID NLM: 101128963

Informations de publication

Date de publication:
05 2021
Historique:
received: 09 11 2020
revised: 21 01 2021
accepted: 02 02 2021
pubmed: 9 2 2021
medline: 20 4 2021
entrez: 8 2 2021
Statut: ppublish

Résumé

Aging is characterized by a progressive loss of tissue integrity and functionality due to disrupted homeostasis. Molecular oxygen is pivotal to maintain tissue functions, and aerobic species have evolved a sophisticated sensing system to ensure proper oxygen supply and demand. It is not surprising that aberrations in oxygen and oxygen-associated pathways subvert health and promote different aspects of aging. In this review, we discuss emerging findings on how oxygen-sensing mechanisms regulate different cellular and molecular processes during normal physiology, and how dysregulation of oxygen availability lead to disease and aging. We describe various clinical manifestations associated with deregulation of oxygen balance, and how oxygen-modulating therapies and natural oxygen oscillations influence longevity. We conclude by discussing how a better understanding of oxygen-related mechanisms that orchestrate aging processes may lead to the development of new therapeutic strategies to extend healthy aging.

Identifiants

DOI: 10.1016/j.arr.2021.101267 PMID: 33556549
pubmed: 33556549
pii: S1568-1637(21)00014-3
doi: 10.1016/j.arr.2021.101267
pii:
doi:

Substances chimiques

Reactive Oxygen Species 0
Oxygen S88TT14065

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

101267

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

T van Vliet (T)

European Research Institute for the Biology of Ageing (ERIBA), University Medical Centre Groningen, the Netherlands.

F Casciaro (F)

University of Padova, Italy.

M Demaria (M)

European Research Institute for the Biology of Ageing (ERIBA), University Medical Centre Groningen, the Netherlands. Electronic address: m.demaria@umcg.nl.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › To breathe or not to breathe: Understanding...
questionsmedicales.fr › Phénomènes physiologiques › Longévité › To breathe or not to breathe: Understanding...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › To breathe or not to breathe: Understanding...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › To breathe or not to breathe: Understanding...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › To breathe or not to breathe: Understanding...