Relevance of pathogenicity prediction tools in human RYR1 variants of unknown significance.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
09 02 2021
Historique:
received: 12 01 2020
accepted: 29 12 2020
entrez: 10 2 2021
pubmed: 11 2 2021
medline: 12 11 2021
Statut: epublish

Résumé

Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle metabolism characterized by generalized muscle rigidity, increased body temperature, rhabdomyolysis, hyperkalemia and severe metabolic acidosis. The underlying mechanism of MH involves excessive Ca

Identifiants

pubmed: 33564012
doi: 10.1038/s41598-021-82024-7
pii: 10.1038/s41598-021-82024-7
pmc: PMC7873245
doi:

Substances chimiques

CACNA1S protein, human 0
Calcium Channels, L-Type 0
RYR1 protein, human 0
Ryanodine Receptor Calcium Release Channel 0

Types de publication

Clinical Trial Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3445

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Auteurs

Kerstin Hoppe (K)

Department of Anesthesiology, Intensive Care Medicine and Pain Therapie, University of Wuerzburg, Oberduerrbacher Straße 6, 97080, Wuerzburg, Germany.
Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University of Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

Karin Jurkat-Rott (K)

Division of Experimental Anesthesiology, University Medical Center Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.

Stefanie Kranepuhl (S)

Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University of Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

Scott Wearing (S)

Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, 4059, Australia.
Department of Conservative and Rehabilitation Orthopedics, Faculty of Sport and Health Science, Technical University of Munich, Georg-Brauchle-Ring 60/62, Munich, Germany.

Sebastian Heiderich (S)

Clinic of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.

Sonja Merlak (S)

Division of Experimental Anesthesiology, University Medical Center Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.

Werner Klingler (W)

Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, 4059, Australia. Werner.Klingler@uni-ulm.de.
Department of Conservative and Rehabilitation Orthopedics, Faculty of Sport and Health Science, Technical University of Munich, Georg-Brauchle-Ring 60/62, Munich, Germany. Werner.Klingler@uni-ulm.de.
Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, SRH Clinic, Hohenzollernstraße 40, Sigmaringen, Germany. Werner.Klingler@uni-ulm.de.

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Classifications MeSH