Thalamic energy dysfunction is associated with thalamo-cortical tract damage in multiple sclerosis: A diffusion spectroscopy study.

Anisotropy Diffusion Magnetic Resonance Imaging Humans Magnetic Resonance Spectroscopy Multiple Sclerosis / diagnostic imaging Thalamus / diagnostic imaging
Multiple sclerosis diffusion tensor imaging diffusion-weighted spectroscopy energy dysfunction neurodegeneration tractography

Journal

Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185

Informations de publication

Date de publication:
04 2021
Historique:
pubmed: 11 2 2021
medline: 25 9 2021
entrez: 10 2 2021
Statut: ppublish

Résumé

Diffusion-weighted To investigate whether thalamic ADC(tCr) changes are associated with thalamo-cortical tract damage in MS. Twenty patients with MS and 13 healthy controls (HC) were enrolled in a DW-MRS and DW imaging (DWI) study. From DW-MRS, ADC(tCr) and total N-acetyl-aspartate diffusivity (ADC(tNAA)) were extracted in the thalami. Three thalamo-cortical tracts and one non-thalamic control tract were reconstructed from DWI. Fractional anisotropy (FA), mean (MD), axial (AD), and radial diffusivity (RD), reflecting microstructural integrity, were extracted for each tract. Associations between thalamic ADC(tCr) and tract metrics were assessed using linear regression models adjusting for age, sex, thalamic volume, thalamic ADC(tNAA), and tract-specific lesion load. Lower thalamic ADC(tCr) was associated with higher MD and RD of thalamo-cortical projections in MS (MD: Reduced thalamic ADC(tCr) correlates with thalamo-cortical tract damage in MS, showing that pathologic changes in thalamic energy metabolism are associated with structural degeneration of connected fibers.

Sections du résumé

BACKGROUND
Diffusion-weighted
OBJECTIVE
To investigate whether thalamic ADC(tCr) changes are associated with thalamo-cortical tract damage in MS.
METHODS
Twenty patients with MS and 13 healthy controls (HC) were enrolled in a DW-MRS and DW imaging (DWI) study. From DW-MRS, ADC(tCr) and total N-acetyl-aspartate diffusivity (ADC(tNAA)) were extracted in the thalami. Three thalamo-cortical tracts and one non-thalamic control tract were reconstructed from DWI. Fractional anisotropy (FA), mean (MD), axial (AD), and radial diffusivity (RD), reflecting microstructural integrity, were extracted for each tract. Associations between thalamic ADC(tCr) and tract metrics were assessed using linear regression models adjusting for age, sex, thalamic volume, thalamic ADC(tNAA), and tract-specific lesion load.
RESULTS
Lower thalamic ADC(tCr) was associated with higher MD and RD of thalamo-cortical projections in MS (MD:
CONCLUSION
Reduced thalamic ADC(tCr) correlates with thalamo-cortical tract damage in MS, showing that pathologic changes in thalamic energy metabolism are associated with structural degeneration of connected fibers.

Identifiants

DOI: 10.1177/1352458520921362 PMID: 33566723
pubmed: 33566723
doi: 10.1177/1352458520921362
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

528-538

Auteurs

Vito Ag Ricigliano (VA)

Sorbonne University, Paris Brain Institute, ICM, Pitié Salpêtrière Hospital, Inserm UMR S 1127, CNRS UMR 7225, Paris, France.
ORCID: 0000-0002-8860-3548

Matteo Tonietto (M)

Sorbonne University, Paris Brain Institute, ICM, Pitié Salpêtrière Hospital, Inserm UMR S 1127, CNRS UMR 7225, Paris, France / Paris-Saclay University, CEA, CNRS, Inserm, BioMaps, Service Hospitalier Fréderic Joliot, Orsay, France.

Raffaele Palladino (R)

Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, UK/Department of Public Health, University of Naples Federico II, Naples, Italy.

Emilie Poirion (E)

Sorbonne University, Paris Brain Institute, ICM, Pitié Salpêtrière Hospital, Inserm UMR S 1127, CNRS UMR 7225, Paris, France.

Alberto De Luca (A)

Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.

Francesca Branzoli (F)

Sorbonne University, Paris Brain Institute, ICM, Pitié Salpêtrière Hospital, Inserm UMR S 1127, CNRS UMR 7225, Paris, France / Centre de Neuroimagerie de la Recherche, Paris Brain Institute, ICM, Paris, France.
ORCID: 0000-0001-9792-0492

Geraldine Bera (G)

Sorbonne University, Paris Brain Institute, ICM, Pitié Salpêtrière Hospital, Inserm UMR S 1127, CNRS UMR 7225, Paris, France.

Elisabeth Maillart (E)

Pitié Salpêtrière Hospital, APHP, Paris, France.
ORCID: 0000-0001-7699-0328

Bruno Stankoff (B)

Sorbonne University, Paris Brain Institute, ICM, Pitié Salpêtrière Hospital, Inserm UMR S 1127, CNRS UMR 7225, Paris, France / Neurology Department, St Antoine Hospital, APHP, Paris, France.

Benedetta Bodini (B)

Sorbonne University, Paris Brain Institute, ICM, Pitié Salpêtrière Hospital, Inserm UMR S 1127, CNRS UMR 7225, Paris, France / Neurology Department, St Antoine Hospital, APHP, Paris, France.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Anisotropie › Thalamic energy dysfunction is associated with...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Imagerie par résonance magnétique de diffusion › Thalamic energy dysfunction is associated with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Thalamic energy dysfunction is associated with...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Thalamic energy dysfunction is associated with...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Thalamic energy dysfunction is associated with...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Thalamus › Thalamic energy dysfunction is associated with...