Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator.

Animals Cell Line Chromatin / genetics Disease Models, Animal Extremities Female Homeodomain Proteins / genetics Humans Limb Deformities, Congenital / genetics Mice Mice, Transgenic RNA, Long Noncoding / genetics Sequence Deletion / genetics Transcription, Genetic Transcriptional Activation / genetics

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
04 2021
Historique:
received: 05 10 2019
accepted: 07 01 2021
pubmed: 12 2 2021
medline: 10 4 2021
entrez: 11 2 2021
Statut: ppublish

Résumé

Long non-coding RNAs (lncRNAs) can be important components in gene-regulatory networks

Identifiants

DOI: 10.1038/s41586-021-03208-9 PMID: 33568816
pubmed: 33568816
doi: 10.1038/s41586-021-03208-9
pii: 10.1038/s41586-021-03208-9
doi:

Substances chimiques

Chromatin 0
EN1 protein, human 0
Homeodomain Proteins 0
RNA, Long Noncoding 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

93-98

Subventions

Organisme : Wellcome Trust
ID : 206475/Z/17/Z
Pays : United Kingdom

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Auteurs

Lila Allou (L)

RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Sara Balzano (S)

Medical Genetics Unit, Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Division of Genetic Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

Andreas Magg (A)

RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany.
ORCID: 0000-0003-4032-0175

Mathieu Quinodoz (M)

Medical Genetics Unit, Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.
Department of Ophthalmology, University of Basel, Basel, Switzerland.

Beryl Royer-Bertrand (B)

Division of Genetic Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

Robert Schöpflin (R)

RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Wing-Lee Chan (WL)

Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Carlos E Speck-Martins (CE)

Genetic Unit, SARAH Network of Rehabilitation Hospitals, Brasilia, Brazil.

Daniel Rocha Carvalho (DR)

Genetic Unit, SARAH Network of Rehabilitation Hospitals, Brasilia, Brazil.

Luciano Farage (L)

Instituto de Cardiologia do Distrito Federal, Brasilia, Brazil.
ORCID: 0000-0002-2293-3771

Charles Marques Lourenço (CM)

Faculdade de Medicina, Centro Universitario Estácio, Ribeirão Preto, Brazil.
ORCID: 0000-0002-2296-6098

Regina Albuquerque (R)

Faculdade Estadual de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil.

Srilakshmi Rajagopal (S)

Department of Medical Genetics, Tamil Nadu Dr M.G.R. Medical University, Chennai, India.

Sheela Nampoothiri (S)

Department of Pediatric Genetics, Amrita Institute of Medical Sciences & Research Centre, Cochin, India.
ORCID: 0000-0002-9575-0722

Belinda Campos-Xavier (B)

Division of Genetic Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

Carole Chiesa (C)

Division of Genetic Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

Florence Niel-Bütschi (F)

Division of Genetic Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

Lars Wittler (L)

Department of Developmental Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany.

Bernd Timmermann (B)

Sequencing Core Facility, Max Planck Institute for Molecular Genetics, Berlin, Germany.

Malte Spielmann (M)

RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Institut für Humangenetik Lübeck, Universität zu Lübeck, Lübeck, Germany.

Michael I Robson (MI)

RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.
ORCID: 0000-0003-1126-3538

Alessa Ringel (A)

RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.

Verena Heinrich (V)

Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.

Giulia Cova (G)

RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Guillaume Andrey (G)

RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Department of Genetic Medicine and Development and iGE3, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
ORCID: 0000-0002-0911-4907

Cesar A Prada-Medina (CA)

RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany.

Rosanna Pescini-Gobert (R)

Medical Genetics Unit, Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
ORCID: 0000-0002-2434-7530

Sheila Unger (S)

Division of Genetic Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

Luisa Bonafé (L)

Division of Genetic Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

Phillip Grote (P)

Institute of Cardiovascular Regeneration, Center for Molecular Medicine, Goethe University, Frankfurt am Main, Germany.
ORCID: 0000-0002-9254-1458

Carlo Rivolta (C)

Medical Genetics Unit, Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.
Department of Ophthalmology, University of Basel, Basel, Switzerland.
Department of Genetics and Genome Biology, University of Leicester, Leicester, UK.
ORCID: 0000-0002-0733-9950

Stefan Mundlos (S)

RG Development & Disease, Max Planck Institute for Molecular Genetics, Berlin, Germany. mundlos@molgen.mpg.de.
Institute for Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany. mundlos@molgen.mpg.de.
Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany. mundlos@molgen.mpg.de.
ORCID: 0000-0002-9788-3166

Andrea Superti-Furga (A)

Division of Genetic Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
ORCID: 0000-0002-3543-7531

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Non-coding deletions identify Maenli lncRNA as...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Non-coding deletions identify Maenli lncRNA as...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Non-coding deletions identify Maenli lncRNA as...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Non-coding deletions identify Maenli lncRNA as...
questionsmedicales.fr › Régions du corps › Membres › Non-coding deletions identify Maenli lncRNA as...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › Non-coding deletions identify Maenli lncRNA as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Non-coding deletions identify Maenli lncRNA as...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations de l'appareil locomoteur › Anomalies morphologiques congénitales des membres › Non-coding deletions identify Maenli lncRNA as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Non-coding deletions identify Maenli lncRNA as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Non-coding deletions identify Maenli lncRNA as...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › Non-coding deletions identify Maenli lncRNA as...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Non-coding deletions identify Maenli lncRNA as...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Non-coding deletions identify Maenli lncRNA as...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Activation de la transcription › Non-coding deletions identify Maenli lncRNA as...