Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.

Cytochrome P-450 CYP2D6 / genetics Genetic Variation / genetics Genome, Human / genetics Genomics Haplotypes / genetics Heterozygote Humans INDEL Mutation Loss of Function Mutation Mutagenesis National Heart, Lung, and Blood Institute (U.S.) Phenotype Polymorphism, Single Nucleotide Population Density Precision Medicine / standards Quality Control Sample Size United States Whole Genome Sequencing / standards

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
02 2021
Historique:
received: 06 03 2019
accepted: 07 01 2021
entrez: 11 2 2021
pubmed: 12 2 2021
medline: 10 3 2021
Statut: ppublish

Résumé

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of improving diagnosis, treatment and prevention of these diseases. The initial phases of the programme focused on whole-genome sequencing of individuals with rich phenotypic data and diverse backgrounds. Here we describe the TOPMed goals and design as well as the available resources and early insights obtained from the sequence data. The resources include a variant browser, a genotype imputation server, and genomic and phenotypic data that are available through dbGaP (Database of Genotypes and Phenotypes)

Identifiants

DOI: 10.1038/s41586-021-03205-y PMID: 33568819 PMC: PMC7875770
pubmed: 33568819
doi: 10.1038/s41586-021-03205-y
pii: 10.1038/s41586-021-03205-y
pmc: PMC7875770
mid: NIHMS1675193
doi:

Substances chimiques

Cytochrome P-450 CYP2D6 EC 1.14.14.1

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

290-299

Subventions

Organisme : NHGRI NIH HHS
ID : R35 HG010692
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES010126
Pays : United States
Organisme : NHLBI NIH HHS
ID : P50 HL118006
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG000040
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL090620
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL141601
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL148521
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111314
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132476
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117626
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131565
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL132825
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA044283
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL123915
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NHLBI NIH HHS
ID : R03 HL141439
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG059898
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL155742
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL120393
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117445
Pays : United States
Organisme : NHLBI NIH HHS
ID : UH3 HL151865
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL163972
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR072199
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142711
Pays : United States
Organisme : BLRD VA
ID : I01 BX005295
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL113326
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL137162
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG005701
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM075091
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007085
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA037904
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL123677
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NHLBI NIH HHS
ID : R03 HL154284
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD012765
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA182913
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG009088
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK078616
Pays : United States
Organisme : NHLBI NIH HHS
ID : UG3 HL151865
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149836
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL135405
Pays : United States

Investigateurs

Namiko Abe (N)
Laura Almasy (L)
Seth Ament (S)
Peter Anderson (P)
Pramod Anugu (P)
Deborah Applebaum-Bowden (D)
Tim Assimes (T)
Dimitrios Avramopoulos (D)
Emily Barron-Casella (E)
Terri Beaty (T)
Gerald Beck (G)
Diane Becker (D)
Amber Beitelshees (A)
Takis Benos (T)
Marcos Bezerra (M)
Joshua Bis (J)
Russell Bowler (R)
Ulrich Broeckel (U)
Jai Broome (J)
Karen Bunting (K)
Carlos Bustamante (C)
Erin Buth (E)
Jonathan Cardwell (J)
Vincent Carey (V)
Cara Carty (C)
Richard Casaburi (R)
Peter Castaldi (P)
Mark Chaffin (M)
Christy Chang (C)
Yi-Cheng Chang (YC)
Sameer Chavan (S)
Bo-Juen Chen (BJ)
Wei-Min Chen (WM)
Lee-Ming Chuang (LM)
Ren-Hua Chung (RH)
Suzy Comhair (S)
Elaine Cornell (E)
Carolyn Crandall (C)
James Crapo (J)
Jeffrey Curtis (J)
Coleen Damcott (C)
Sean David (S)
Colleen Davis (C)
Lisa de Las Fuentes (LL)
Michael DeBaun (M)
Ranjan Deka (R)
Scott Devine (S)
Qing Duan (Q)
Ravi Duggirala (R)
Jon Peter Durda (JP)
Charles Eaton (C)
Lynette Ekunwe (L)
Adel El Boueiz (A)
Serpil Erzurum (S)
Charles Farber (C)
Matthew Flickinger (M)
Myriam Fornage (M)
Chris Frazar (C)
Mao Fu (M)
Lucinda Fulton (L)
Shanshan Gao (S)
Yan Gao (Y)
Margery Gass (M)
Bruce Gelb (B)
Xiaoqi Priscilla Geng (XP)
Mark Geraci (M)
Auyon Ghosh (A)
Chris Gignoux (C)
David Glahn (D)
Da-Wei Gong (DW)
Harald Goring (H)
Sharon Graw (S)
Daniel Grine (D)
C Charles Gu (CC)
Yue Guan (Y)
Namrata Gupta (N)
Jeff Haessler (J)
Nicola L Hawley (NL)
Ben Heavner (B)
David Herrington (D)
Craig Hersh (C)
Bertha Hidalgo (B)
James Hixson (J)
Brian Hobbs (B)
John Hokanson (J)
Elliott Hong (E)
Karin Hoth (K)
Chao Agnes Hsiung (CA)
Yi-Jen Hung (YJ)
Haley Huston (H)
Chii Min Hwu (CM)
Rebecca Jackson (R)
Deepti Jain (D)
Min A Jhun (MA)
Craig Johnson (C)
Rich Johnston (R)
Kimberly Jones (K)
Sekar Kathiresan (S)
Alyna Khan (A)
Wonji Kim (W)
Greg Kinney (G)
Holly Kramer (H)
Christoph Lange (C)
Ethan Lange (E)
Leslie Lange (L)
Cecelia Laurie (C)
Meryl LeBoff (M)
Jiwon Lee (J)
Seunggeun Shawn Lee (SS)
Wen-Jane Lee (WJ)
David Levine (D)
Joshua Lewis (J)
Xiaohui Li (X)
Yun Li (Y)
Henry Lin (H)
Honghuang Lin (H)
Keng Han Lin (KH)
Simin Liu (S)
Yongmei Liu (Y)
Yu Liu (Y)
James Luo (J)
Michael Mahaney (M)
Barry Make (B)
JoAnn Manson (J)
Lauren Margolin (L)
Lisa Martin (L)
Susan Mathai (S)
Susanne May (S)
Patrick McArdle (P)
Merry-Lynn McDonald (ML)
Sean McFarland (S)
Daniel McGoldrick (D)
Caitlin McHugh (C)
Hao Mei (H)
Luisa Mestroni (L)
Nancy Min (N)
Ryan L Minster (RL)
Matt Moll (M)
Arden Moscati (A)
Solomon Musani (S)
Stanford Mwasongwe (S)
Josyf C Mychaleckyj (JC)
Girish Nadkarni (G)
Rakhi Naik (R)
Take Naseri (T)
Sergei Nekhai (S)
Bonnie Neltner (B)
Heather Ochs-Balcom (H)
David Paik (D)
James Pankow (J)
Afshin Parsa (A)
Juan Manuel Peralta (JM)
Marco Perez (M)
James Perry (J)
Ulrike Peters (U)
Lawrence S Phillips (LS)
Toni Pollin (T)
Julia Powers Becker (JP)
Meher Preethi Boorgula (MP)
Michael Preuss (M)
Dandi Qiao (D)
Zhaohui Qin (Z)
Nicholas Rafaels (N)
Laura Raffield (L)
Laura Rasmussen-Torvik (L)
Aakrosh Ratan (A)
Robert Reed (R)
Elizabeth Regan (E)
Muagututi'a Sefuiva Reupena (MS)
Carolina Roselli (C)
Pamela Russell (P)
Sarah Ruuska (S)
Kathleen Ryan (K)
Ester Cerdeira Sabino (EC)
Danish Saleheen (D)
Shabnam Salimi (S)
Steven Salzberg (S)
Kevin Sandow (K)
Vijay G Sankaran (VG)
Christopher Scheller (C)
Ellen Schmidt (E)
Karen Schwander (K)
Frank Sciurba (F)
Christine Seidman (C)
Jonathan Seidman (J)
Stephanie L Sherman (SL)
Aniket Shetty (A)
Wayne Hui-Heng Sheu (WH)
Brian Silver (B)
Josh Smith (J)
Tanja Smith (T)
Sylvia Smoller (S)
Beverly Snively (B)
Michael Snyder (M)
Tamar Sofer (T)
Garrett Storm (G)
Elizabeth Streeten (E)
Yun Ju Sung (YJ)
Jody Sylvia (J)
Adam Szpiro (A)
Carole Sztalryd (C)
Hua Tang (H)
Margaret Taub (M)
Matthew Taylor (M)
Simeon Taylor (S)
Machiko Threlkeld (M)
Lesley Tinker (L)
David Tirschwell (D)
Sarah Tishkoff (S)
Hemant Tiwari (H)
Catherine Tong (C)
Michael Tsai (M)
Dhananjay Vaidya (D)
Peter VandeHaar (P)
Tarik Walker (T)
Robert Wallace (R)
Avram Walts (A)
Fei Fei Wang (FF)
Heming Wang (H)
Karol Watson (K)
Jennifer Wessel (J)
Kayleen Williams (K)
L Keoki Williams (LK)
Carla Wilson (C)
Joseph Wu (J)
Huichun Xu (H)
Lisa Yanek (L)
Ivana Yang (I)
Rongze Yang (R)
Norann Zaghloul (N)
Maryam Zekavat (M)
Snow Xueyan Zhao (SX)
Wei Zhao (W)
Degui Zhi (D)
Xiang Zhou (X)
Xiaofeng Zhu (X)

Références

Nature. 2006 Jan 19;439(7074):331-5
pubmed: 16421571
Nature. 2020 May;581(7809):434-443
pubmed: 32461654
PLoS Genet. 2009 May;5(5):e1000471
pubmed: 19424416
PLoS Genet. 2016 Nov 15;12(11):e1006315
pubmed: 27846220
PLoS Genet. 2018 Jun 18;14(6):e1007387
pubmed: 29912945
Nat Genet. 2016 Nov;48(11):1443-1448
pubmed: 27694958
Am J Hum Genet. 2013 Aug 8;93(2):278-88
pubmed: 23910464
Genome Res. 2020 Feb;30(2):185-194
pubmed: 31980570
Genetics. 2017 Jul;206(3):1549-1567
pubmed: 28495960
Microbiol Mol Biol Rev. 2009 Mar;73(1):134-54
pubmed: 19258535
Genet Epidemiol. 2015 May;39(4):276-93
pubmed: 25810074
Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14938-43
pubmed: 21873224
Nature. 2017 Sep 28;549(7673):519-522
pubmed: 28959963
Am J Hum Genet. 2015 Sep 3;97(3):404-18
pubmed: 26299365
BMC Med Genet. 2010 May 02;11:68
pubmed: 20433770
Proc Natl Acad Sci U S A. 1985 Jun;82(11):3771-5
pubmed: 2987944
Nature. 2012 Nov 1;491(7422):56-65
pubmed: 23128226
Nat Genet. 2016 Oct;48(10):1279-83
pubmed: 27548312
Genome Res. 2014 Sep;24(9):1445-54
pubmed: 25079859
Nat Genet. 2007 Oct;39(10):1181-6
pubmed: 17898773
Nucleic Acids Res. 2015 Jan;43(Database issue):D805-11
pubmed: 25355519
Am J Hum Genet. 2007 Nov;81(5):1084-97
pubmed: 17924348
Am J Hum Genet. 2015 Dec 3;97(6):775-89
pubmed: 26581902
Annu Rev Genomics Hum Genet. 2018 Aug 31;19:73-96
pubmed: 29799802
Cell. 2019 Jan 24;176(3):663-675.e19
pubmed: 30661756
Curr Opin Genet Dev. 2018 Dec;53:140-147
pubmed: 30366252
Proc Natl Acad Sci U S A. 1984 May;81(10):3024-8
pubmed: 6374651
Genetics. 2016 Nov;204(3):1207-1223
pubmed: 27605051
Nature. 2015 Oct 1;526(7571):82-90
pubmed: 26367797
Science. 2008 Feb 22;319(5866):1100-4
pubmed: 18292342
Nat Commun. 2018 Sep 14;9(1):3753
pubmed: 30218074
Genome Res. 2010 Sep;20(9):1297-303
pubmed: 20644199
Am J Hum Genet. 2008 Feb;82(2):411-23
pubmed: 18252221
Nat Genet. 2016 Oct;48(10):1284-1287
pubmed: 27571263
Genetics. 2016 Jan;202(1):235-45
pubmed: 26450922
Pharmacol Ther. 1995 May;66(2):191-205
pubmed: 7667395
Genome Biol. 2016 Jun 06;17(1):122
pubmed: 27268795
Genome Res. 2015 Jun;25(6):918-25
pubmed: 25883319
Science. 2007 Aug 17;317(5840):915
pubmed: 17702936
Curr Biol. 2018 Apr 2;28(7):1157-1165.e7
pubmed: 29501328
Genome Biol. 2017 Feb 27;18(1):42
pubmed: 28241850
Nat Genet. 2017 Apr;49(4):588-593
pubmed: 28250455
PLoS Genet. 2016 Dec 15;12(12):e1006489
pubmed: 27977673
Eur J Biochem. 1985 Nov 15;153(1):13-28
pubmed: 4065146
Nat Genet. 2020 Sep;52(9):969-983
pubmed: 32839606
Mol Biol Evol. 2016 Feb;33(2):591-3
pubmed: 26545922
PLoS Genet. 2010 Aug 26;6(8):
pubmed: 20865123
Nat Genet. 2000 May;25(1):25-9
pubmed: 10802651
Clin Pharmacol Ther. 2019 Dec;106(6):1328-1337
pubmed: 31206625
Nat Genet. 2018 Sep;50(9):1335-1341
pubmed: 30104761
Nature. 2016 Aug 17;536(7616):285-91
pubmed: 27535533
Am J Hum Genet. 2019 Nov 7;105(5):883-893
pubmed: 31587867
Mol Ecol. 2016 Jan;25(1):135-41
pubmed: 26394805
Nat Genet. 2018 Apr;50(4):487-492
pubmed: 29507425
Heredity (Edinb). 2006 Jan;96(1):7-21
pubmed: 16094301
J Evol Biol. 2003 May;16(3):363-77
pubmed: 14635837
Nat Commun. 2018 Oct 2;9(1):4038
pubmed: 30279509
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11983-8
pubmed: 21730125
N Engl J Med. 2009 May 7;360(19):1971-80
pubmed: 19420366
Am J Hum Genet. 1999 Apr;64(4):1147-57
pubmed: 10090900
Nucleic Acids Res. 2005 Jan 1;33(Database issue):D514-7
pubmed: 15608251
Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9562-7
pubmed: 9275162
Clin Pharmacol Ther. 2014 Apr;95(4):376-82
pubmed: 24458010
Nucleic Acids Res. 2018 Jan 4;46(D1):D762-D769
pubmed: 29106570
Nature. 2018 Oct;562(7726):203-209
pubmed: 30305743
J Med Genet. 2016 Feb;53(2):111-2
pubmed: 26395054
Nucleic Acids Res. 2018 Jan 4;46(D1):D754-D761
pubmed: 29155950
Genet Med. 2019 Feb;21(2):361-372
pubmed: 29875422
Nature. 2007 Oct 18;449(7164):851-61
pubmed: 17943122
Nat Genet. 2014 Mar;46(3):310-5
pubmed: 24487276
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Nucleic Acids Res. 2019 Jan 8;47(D1):D766-D773
pubmed: 30357393
Science. 2010 May 7;328(5979):710-722
pubmed: 20448178
Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9458-9465
pubmed: 32291332
Curr Biol. 2010 Nov 23;20(22):1983-92
pubmed: 21074440
Bioinformatics. 2016 May 1;32(9):1366-72
pubmed: 26722118
Genome Res. 2017 Sep;27(9):1597-1607
pubmed: 28774965
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15942-7
pubmed: 16243969
BMC Genomics. 2014 Jun 06;15:437
pubmed: 24906912
Am J Hum Genet. 2018 Oct 4;103(4):522-534
pubmed: 30269813
Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12452-6
pubmed: 9356470
Nucleic Acids Res. 2017 Jan 4;45(D1):D331-D338
pubmed: 27899567
Science. 2012 Jul 6;337(6090):64-9
pubmed: 22604720
Nat Rev Genet. 2010 Jun;11(6):415-25
pubmed: 20479773
Nat Genet. 2019 Jan;51(1):30-35
pubmed: 30455414
Am J Hum Genet. 2016 May 5;98(5):857-868
pubmed: 27087321
Genetics. 2013 Jun;194(2):459-71
pubmed: 23535385
Nature. 2013 Jan 10;493(7431):216-20
pubmed: 23201682
Clin Pharmacokinet. 2009;48(11):689-723
pubmed: 19817501
PLoS Genet. 2019 Dec 23;15(12):e1008500
pubmed: 31869403
Nature. 2020 Oct;586(7831):749-756
pubmed: 33087929
Nucleic Acids Res. 2014 Jan;42(Database issue):D1001-6
pubmed: 24316577
Genome Res. 2005 Sep;15(9):1222-31
pubmed: 16140990
Science. 2016 Nov 11;354(6313):760-764
pubmed: 27738015
Elife. 2020 Jun 23;9:
pubmed: 32573438
Nature. 2020 Oct;586(7831):763-768
pubmed: 33057201
Nucleic Acids Res. 2018 Jan 4;46(D1):D1062-D1067
pubmed: 29165669

Auteurs

Daniel Taliun (D)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Daniel N Harris (DN)

Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Michael D Kessler (MD)

Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Jedidiah Carlson (J)

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Department of Genome Sciences, University of Washington, Seattle, WA, USA.

Zachary A Szpiech (ZA)

Department of Biology, Pennsylvania State University, University Park, PA, USA.
Institute for Computational and Data Sciences, Pennsylvania State University, University Park, PA, USA.

Raul Torres (R)

Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.

Sarah A Gagliano Taliun (SAG)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0003-1306-1868

André Corvelo (A)

New York Genome Center, New York, NY, USA.
ORCID: 0000-0003-0989-7806

Stephanie M Gogarten (SM)

Department of Biostatistics, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-7231-9745

Hyun Min Kang (HM)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Achilleas N Pitsillides (AN)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Jonathon LeFaive (J)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0003-3668-6086

Seung-Been Lee (SB)

Department of Genome Sciences, University of Washington, Seattle, WA, USA.
ORCID: 0000-0001-9869-1070

Xiaowen Tian (X)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Brian L Browning (BL)

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA.

Sayantan Das (S)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0001-6346-1590

Anne-Katrin Emde (AK)

New York Genome Center, New York, NY, USA.

Wayne E Clarke (WE)

New York Genome Center, New York, NY, USA.

Douglas P Loesch (DP)

Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Amol C Shetty (AC)

Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0001-8790-7649

Thomas W Blackwell (TW)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Albert V Smith (AV)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
ORCID: 0000-0003-1942-5845

Quenna Wong (Q)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Xiaoming Liu (X)

USF Genomics, College of Public Health, University of South Florida, Tampa, FL, USA.

Matthew P Conomos (MP)

Department of Biostatistics, University of Washington, Seattle, WA, USA.
ORCID: 0000-0001-9744-0851

Dean M Bobo (DM)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

François Aguet (F)

The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Christine Albert (C)

Massachusetts General Hospital, Boston, MA, USA.

Alvaro Alonso (A)

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Kristin G Ardlie (KG)

The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Dan E Arking (DE)

McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Stella Aslibekyan (S)

University of Alabama, Birmingham, AL, USA.

Paul L Auer (PL)

Zilber School of Public Health, University of Wisconsin Milwaukee, Milwaukee, WI, USA.

John Barnard (J)

Cleveland Clinic, Cleveland, OH, USA.

R Graham Barr (RG)

Department of Medicine, Columbia University Medical Center, New York, NY, USA.
Department of Epidemiology, Columbia University Medical Center, New York, NY, USA.

Lucas Barwick (L)

The Emmes Corporation, Rockville, MD, USA.

Lewis C Becker (LC)

Johns Hopkins University, Baltimore, MD, USA.

Rebecca L Beer (RL)

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Emelia J Benjamin (EJ)

Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Framingham Heart Study, Framingham, MA, USA.

Lawrence F Bielak (LF)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.

John Blangero (J)

Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.

Michael Boehnke (M)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Donald W Bowden (DW)

Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Jennifer A Brody (JA)

Department of Medicine, University of Washington, Seattle, WA, USA.
Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.

Esteban G Burchard (EG)

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

Brian E Cade (BE)

Department of Medicine, Harvard Medical School, Boston, MA, USA.
Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

James F Casella (JF)

Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA.
Division of Pediatric Hematology, Johns Hopkins University, Baltimore, MD, USA.

Brandon Chalazan (B)

Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

Daniel I Chasman (DI)

Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Yii-Der Ida Chen (YI)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.

Michael H Cho (MH)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Seung Hoan Choi (SH)

The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Mina K Chung (MK)

Department of Cardiovascular Medicine, Heart & Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.
Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.

Clary B Clish (CB)

Metabolomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Adolfo Correa (A)

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, USA.
Department of Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA.

Joanne E Curran (JE)

Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.

Brian Custer (B)

Vitalant Research Institute, San Francisco, CA, USA.
Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Dawood Darbar (D)

Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

Michelle Daya (M)

Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Mariza de Andrade (M)

Mayo Clinic, Rochester, MN, USA.

Dawn L DeMeo (DL)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Susan K Dutcher (SK)

McDonnell Genome Institute, Washington University, St Louis, MO, USA.
Department of Genetics, Washington University, St Louis, MO, USA.

Patrick T Ellinor (PT)

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Leslie S Emery (LS)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Celeste Eng (C)

Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

Diane Fatkin (D)

Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Faculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia.
Cardiology Department, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.

Tasha Fingerlin (T)

National Jewish Health, Center for Genes, Environment and Health, Denver, CO, USA.

Lukas Forer (L)

Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.

Myriam Fornage (M)

Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.

Nora Franceschini (N)

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.

Christian Fuchsberger (C)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Institute for Biomedicine, Eurac Research, Bolzano, Italy.

Stephanie M Fullerton (SM)

Department of Bioethics & Humanities, University of Washington School of Medicine, Seattle, WA, USA.

Soren Germer (S)

New York Genome Center, New York, NY, USA.

Mark T Gladwin (MT)

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Daniel J Gottlieb (DJ)

VA Boston Healthcare System, Boston, MA, USA.
Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.

Xiuqing Guo (X)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.

Michael E Hall (ME)

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

Jiang He (J)

Department of Epidemiology, Tulane University, New Orleans, LA, USA.
Tulane University Translational Science Institute, Tulane University, New Orleans, LA, USA.

Nancy L Heard-Costa (NL)

Framingham Heart Study, Framingham, MA, USA.
Department of Neurology, Boston University School of Medicine, Boston, MA, USA.

Susan R Heckbert (SR)

Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.

Marguerite R Irvin (MR)

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.

Jill M Johnsen (JM)

Department of Medicine, University of Washington, Seattle, WA, USA.
Bloodworks Northwest Research Institute, Seattle, WA, USA.

Andrew D Johnson (AD)

Framingham Heart Study, Framingham, MA, USA.
Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA, USA.

Robert Kaplan (R)

Albert Einstein College of Medicine, New York, NY, USA.

Sharon L R Kardia (SLR)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Tanika Kelly (T)

Department of Epidemiology, Tulane University, New Orleans, LA, USA.

Shannon Kelly (S)

Department of Epidemiology, Vitalant Research Institute, San Francisco, CA, USA.
Department of Pediatrics, UCSF Benioff Children's Hospital, Oakland, CA, USA.
Division of Pediatric Hematology, UCSF Benioff Children's Hospital, Oakland, CA, USA.

Eimear E Kenny (EE)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Douglas P Kiel (DP)

The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.
Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Robert Klemmer (R)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Barbara A Konkle (BA)

Department of Medicine, University of Washington, Seattle, WA, USA.
Bloodworks Northwest Research Institute, Seattle, WA, USA.

Charles Kooperberg (C)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Anna Köttgen (A)

Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.

Leslie A Lange (LA)

Department of Medicine, University of Colorado at Denver, Aurora, CO, USA.

Jessica Lasky-Su (J)

Department of Medicine, Harvard Medical School, Boston, MA, USA.
Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Brigham and Women's Hospital, Boston, MA, USA.

Daniel Levy (D)

Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Framingham Heart Study, Framingham, MA, USA.
Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA, USA.

Xihong Lin (X)

Biostatistics and Statistics, Harvard University, Boston, MA, USA.

Keng-Han Lin (KH)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Chunyu Liu (C)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Ruth J F Loos (RJF)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Lori Garman (L)

Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

Robert Gerszten (R)

Beth Israel Deaconess Medical Center, Boston, MA, USA.

Steven A Lubitz (SA)

Massachusetts General Hospital, Boston, MA, USA.

Kathryn L Lunetta (KL)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Angel C Y Mak (ACY)

Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

Ani Manichaikul (A)

Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.

Alisa K Manning (AK)

Department of Medicine, Harvard Medical School, Boston, MA, USA.
Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA.
Metabolism Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Rasika A Mathias (RA)

Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.

David D McManus (DD)

Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

Stephen T McGarvey (ST)

International Health Institute, Brown University, Providence, RI, USA.
Department of Epidemiology, Brown University, Providence, RI, USA.
Department of Anthropology, Brown University, Providence, RI, USA.

James B Meigs (JB)

Division of General Internal Medicine, Massachusetts General Hospital, Harvard Medical School, The Broad Institute of MIT and Harvard, Boston, MA, USA.

Deborah A Meyers (DA)

University of Arizona, Tucson, AZ, USA.

Julie L Mikulla (JL)

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Mollie A Minear (MA)

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Braxton D Mitchell (BD)

Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.

Sanghamitra Mohanty (S)

Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA.
Department of Internal Medicine, Dell Medical School, Austin, TX, USA.

May E Montasser (ME)

Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Courtney Montgomery (C)

Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

Alanna C Morrison (AC)

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.

Joanne M Murabito (JM)

Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Andrea Natale (A)

Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA.

Pradeep Natarajan (P)

Department of Medicine, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

Sarah C Nelson (SC)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Kari E North (KE)

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.

Jeffrey R O'Connell (JR)

Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Nicholette D Palmer (ND)

Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Nathan Pankratz (N)

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.

Gina M Peloso (GM)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Patricia A Peyser (PA)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Jacob Pleiness (J)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Wendy S Post (WS)

Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Bruce M Psaty (BM)

Department of Medicine, University of Washington, Seattle, WA, USA.
Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.
Department of Health Services, University of Washington, Seattle, WA, USA.
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

D C Rao (DC)

Division of Biostatistics, Washington University in St Louis, St Louis, MO, USA.

Susan Redline (S)

Department of Medicine, Harvard Medical School, Boston, MA, USA.
Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Alexander P Reiner (AP)

Department of Epidemiology, University of Washington, Seattle, WA, USA.
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Dan Roden (D)

Vanderbilt University Medical Center, Nashville, TN, USA.

Jerome I Rotter (JI)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.

Ingo Ruczinski (I)

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Chloé Sarnowski (C)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Sebastian Schoenherr (S)

Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.

David A Schwartz (DA)

University of Colorado at Denver, Denver, CO, USA.

Jeong-Sun Seo (JS)

Precision Medicine Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Macrogen Inc, Seoul, Republic of Korea.
Gong Wu Genomic Medicine Institute, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Sudha Seshadri (S)

Framingham Heart Study, Framingham, MA, USA.
Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA.

Vivien A Sheehan (VA)

Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.

Wayne H Sheu (WH)

Taichung Veterans General Hospital Taiwan, Taichung City, Taiwan.

M Benjamin Shoemaker (MB)

Vanderbilt University Medical Center, Nashville, TN, USA.

Nicholas L Smith (NL)

Department of Epidemiology, University of Washington, Seattle, WA, USA.
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA, USA.

Jennifer A Smith (JA)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.

Nona Sotoodehnia (N)

Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.

Adrienne M Stilp (AM)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Weihong Tang (W)

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.

Kent D Taylor (KD)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA.

Marilyn Telen (M)

Duke University, Durham, NC, USA.

Timothy A Thornton (TA)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Russell P Tracy (RP)

Department of Pathology & Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA.

David J Van Den Berg (DJ)

Center for Genetic Epidemiology, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.

Ramachandran S Vasan (RS)

Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Framingham Heart Study, Framingham, MA, USA.

Karine A Viaud-Martinez (KA)

Illumina Laboratory Services, Illumina Inc, San Diego, CA, USA.

Scott Vrieze (S)

Department of Psychology, University of Minnesota, Minneapolis, MN, USA.

Daniel E Weeks (DE)

Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Bruce S Weir (BS)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Scott T Weiss (ST)

Department of Medicine, Harvard Medical School, Boston, MA, USA.
Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Brigham and Women's Hospital, Boston, MA, USA.

Lu-Chen Weng (LC)

Massachusetts General Hospital, Boston, MA, USA.

Cristen J Willer (CJ)

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor, MI, USA.
Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.

Yingze Zhang (Y)

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Xutong Zhao (X)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Donna K Arnett (DK)

Department of Epidemiology, University of Kentucky, Lexington, KY, USA.

Allison E Ashley-Koch (AE)

Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.

Kathleen C Barnes (KC)

Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Eric Boerwinkle (E)

University of Texas Health Science Center at Houston, Houston, TX, USA.
Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA.

Stacey Gabriel (S)

The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Richard Gibbs (R)

Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA.

Kenneth M Rice (KM)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Stephen S Rich (SS)

Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.

Edwin K Silverman (EK)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Pankaj Qasba (P)

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Weiniu Gan (W)

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

George J Papanicolaou (GJ)

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Deborah A Nickerson (DA)

Department of Genome Sciences, University of Washington, Seattle, WA, USA.
Northwest Genomics Center, Seattle, WA, USA.
Brotman Baty Institute, Seattle, WA, USA.

Sharon R Browning (SR)

Department of Biostatistics, University of Washington, Seattle, WA, USA.
ORCID: 0000-0001-7251-9715

Michael C Zody (MC)

New York Genome Center, New York, NY, USA.

Sebastian Zöllner (S)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.

James G Wilson (JG)

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.

L Adrienne Cupples (LA)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. adrienne@bu.edu.
Framingham Heart Study, Framingham, MA, USA. adrienne@bu.edu.
ORCID: 0000-0003-0273-7965

Cathy C Laurie (CC)

Department of Biostatistics, University of Washington, Seattle, WA, USA. cclaurie@uw.edu.
ORCID: 0000-0003-2572-4040

Cashell E Jaquish (CE)

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. jaquishc@nhlbi.nih.gov.
ORCID: 0000-0003-3319-3729

Ryan D Hernandez (RD)

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA. ryan.hernandez@mcgill.ca.
Department of Human Genetics, McGill University, Montreal, Quebec, Canada. ryan.hernandez@mcgill.ca.
Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA. ryan.hernandez@mcgill.ca.
Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. ryan.hernandez@mcgill.ca.
Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA. ryan.hernandez@mcgill.ca.
ORCID: 0000-0001-5249-504X

Timothy D O'Connor (TD)

Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. timothydoconnor@gmail.com.
Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. timothydoconnor@gmail.com.
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. timothydoconnor@gmail.com.
ORCID: 0000-0002-0276-1896

Gonçalo R Abecasis (GR)

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA. goncalo@umich.edu.
ORCID: 0000-0003-1509-1825

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-2 de cytochromes P450 › Cytochrome P-450 CYP2D6 › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome humain › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Haplotypes › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Hétérozygote › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Mutation de type INDEL › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation perte de fonction › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Organisations et économie des soins de santé › Organismes › Gouvernement › Agences gouvernementale américaines › Department of Health and Human Services (USA) › Public Health Service (USA) › National Institutes of Health (USA) › National Heart, Lung, and Blood Institute (USA) › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › Densité de population › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Contrôle de qualité › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Taille de l'échantillon › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › États-Unis › Sequencing of 53,831 diverse genomes from the...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Sequencing of 53,831 diverse genomes from the...