Multiomics uncovers developing immunological lineages in human.
bioinformatics
developmental immunology
prenatal immunity
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
19
11
2020
received:
01
10
2020
pubmed:
12
2
2021
medline:
21
9
2021
entrez:
11
2
2021
Statut:
ppublish
Résumé
The development of the human immune system during embryonic and fetal life has historically been difficult to research due to limited access to human tissue. Experimental animal models have been widely used to study development but cellular and molecular programmes may not be conserved across species. The advent of multiomic single-cell technologies and an increase in human developmental tissue biobank resources have facilitated single-cell multiomic studies focused on human immune development. A critical question in the near future is "How do we best reconcile scientific findings across multiple omic modalities, developmental time, and organismic space?" In this review, we discuss the application of single-cell multiomic technologies to unravel the major cellular lineages in the prenatal human immune system. We also identify key areas where the combined power of multiomics technologies can be leveraged to address specific immunological gaps in our current knowledge and explore new research horizons in human development.
Identifiants
pubmed: 33569778
doi: 10.1002/eji.202048769
pmc: PMC8600952
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
764-772Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT211276/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT107931/Z/15/Z
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
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