Genetic Variation in the Bitter Receptors Responsible for Epicatechin Detection Are Associated with BMI in an Elderly Cohort.
BMI
bitter
epicatechin
obesity
phenol
taste genetics
taste receptors
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
09 Feb 2021
09 Feb 2021
Historique:
received:
08
01
2021
revised:
01
02
2021
accepted:
07
02
2021
entrez:
12
2
2021
pubmed:
13
2
2021
medline:
3
9
2021
Statut:
epublish
Résumé
Globally, more than one-third of adults are overweight. Overweight and obesity are complex and multifaceted conditions, associated with an increased risk of chronic illness and early mortality. While there are known risk factors, these alone do not fully explain the varying outcomes between individuals. Recently, taste receptors have been proposed to have a role in the risk for obesity. These receptors are expressed throughout the gastrointestinal tract. In this system, they may be involved in modulating dietary intake and metabolic processes. The taste 2 family of receptors (T2Rs) detects bitter compounds. Receptors T2R4 and T2R5 detect (-)-epicatechin (epicatechin), an antioxidant polyphenol, which may have protective effects against obesity. However, the potential role for taste receptors in this association has not been explored. This study assessed whether polymorphisms in
Identifiants
pubmed: 33572225
pii: nu13020571
doi: 10.3390/nu13020571
pmc: PMC7914776
pii:
doi:
Substances chimiques
Receptors, G-Protein-Coupled
0
TAS2R4 protein, human
0
taste receptors, type 2
0
Catechin
8R1V1STN48
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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