Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice.
Animals
Bone Morphogenetic Protein Receptors, Type II
/ genetics
Dendritic Cells
/ immunology
Familial Primary Pulmonary Hypertension
/ genetics
Gene Deletion
Heart Ventricles
/ immunology
Humans
Immunity, Innate
Mice
Mutation
Toll-Like Receptor 4
/ immunology
Tumor Necrosis Factor alpha-Induced Protein 3
/ genetics
BMPR2
Tnfaip3
Toll-like receptor
dendritic cells
inflammation
pulmonary arterial hypertension
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Feb 2021
10 Feb 2021
Historique:
received:
12
01
2021
revised:
05
02
2021
accepted:
06
02
2021
entrez:
13
2
2021
pubmed:
14
2
2021
medline:
20
4
2021
Statut:
epublish
Résumé
The pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) is not fully understood, but evidence is accumulating that immune dysfunction plays a significant role. We previously reported that 31-week-old
Identifiants
pubmed: 33578743
pii: ijms22041756
doi: 10.3390/ijms22041756
pmc: PMC7916474
pii:
doi:
Substances chimiques
Tlr4 protein, mouse
0
Toll-Like Receptor 4
0
Bmpr2 protein, mouse
EC 2.7.11.30
Bone Morphogenetic Protein Receptors, Type II
EC 2.7.11.30
Tumor Necrosis Factor alpha-Induced Protein 3
EC 3.4.19.12
Tnfaip3 protein, mouse
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : British Heart Foundation
ID : CH/09/001/25945
Pays : United Kingdom
Organisme : Hartstichting
ID : 2016T052
Références
J Exp Med. 2009 Oct 26;206(11):2339-49
pubmed: 19808255
Int J Mol Sci. 2018 Aug 24;19(9):
pubmed: 30149506
Immunity. 2017 Mar 21;46(3):457-473
pubmed: 28329706
Eur Respir J. 2007 Mar;29(3):462-8
pubmed: 17107989
Hum Mutat. 2015 Dec;36(12):1113-27
pubmed: 26387786
PLoS One. 2014 Oct 20;9(10):e109291
pubmed: 25329529
Circ Res. 2019 Mar 15;124(6):904-919
pubmed: 30661465
Int J Bioinform Res Appl. 2014;10(6):587-612
pubmed: 25335565
Nat Rev Immunol. 2013 Jun;13(6):397-411
pubmed: 23702978
Int J Rheumatol. 2010;2010:
pubmed: 20936074
Immunology. 2018 May;154(1):3-20
pubmed: 29313948
Curr Opin Immunol. 2021 Feb;68:54-63
pubmed: 33128959
Immunity. 2015 Jan 20;42(1):55-67
pubmed: 25607459
Am J Respir Crit Care Med. 2012 Feb 1;185(3):311-21
pubmed: 22108206
Chest. 2015 Jun;147(6):1610-1620
pubmed: 25429518
J Immunol. 2012 Jun 15;188(12):5981-9
pubmed: 22561154
Nat Med. 2015 Jul;21(7):777-85
pubmed: 26076038
Cell Rep. 2020 Nov 17;33(7):108381
pubmed: 33207188
Cardiovasc Res. 2017 Oct 1;113(12):1441-1452
pubmed: 28957536
Am J Respir Cell Mol Biol. 2020 Nov;63(5):665-680
pubmed: 32755457
Eur Respir J. 2019 Jan 24;53(1):
pubmed: 30545973
Eur Respir J. 2019 Jan 24;53(1):
pubmed: 30545968
Nat Rev Immunol. 2018 Dec;18(12):733-744
pubmed: 30228378
Circulation. 2002 Apr 9;105(14):1672-8
pubmed: 11940546
Nat Rev Cardiol. 2020 Feb;17(2):85-95
pubmed: 31406341
J Cell Mol Med. 2020 Oct;24(19):11409-11421
pubmed: 32860486
Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L98-L111
pubmed: 31617731
J Exp Med. 2009 Nov 23;206(12):2593-601
pubmed: 19917776
Circulation. 2010 Aug 31;122(9):920-7
pubmed: 20713898
Nature. 2014 Aug 7;512(7512):69-73
pubmed: 25043000
Eur Respir J. 2018 Jan 25;51(1):
pubmed: 29371380
Biochem Biophys Res Commun. 2012 Oct 5;426(4):486-91
pubmed: 22960172
J Comput Biol. 2021 Jan;28(1):79-88
pubmed: 32493063
Physiol Rep. 2020 Aug;8(15):e14532
pubmed: 32786064
Cell. 2013 Aug 15;154(4):843-58
pubmed: 23953115
Respir Res. 2011 Sep 09;12:119
pubmed: 21906276
Front Immunol. 2019 Jan 22;10:11
pubmed: 30723471
Expert Rev Respir Med. 2011 Apr;5(2):207-16
pubmed: 21510731
Pulm Circ. 2018 Apr-Jun;8(2):2045894018765840
pubmed: 29521190
J Clin Immunol. 2009 Nov;29(6):705-13
pubmed: 19693657
J Clin Med. 2020 Feb 19;9(2):
pubmed: 32092864
J Allergy Clin Immunol. 2018 May;141(5):1620-1633.e12
pubmed: 28888782
Pulm Pharmacol Ther. 2015 Dec;35:8-16
pubmed: 26403584
Circulation. 2015 Mar 17;131(11):1006-18
pubmed: 25593290