Melatonin alleviates Ochratoxin A-induced liver inflammation involved intestinal microbiota homeostasis and microbiota-independent manner.
Intestinal barrier
Intestinal microbiota
LPS
Liver inflammation
Melatonin
Ochratoxin A
Journal
Journal of hazardous materials
ISSN: 1873-3336
Titre abrégé: J Hazard Mater
Pays: Netherlands
ID NLM: 9422688
Informations de publication
Date de publication:
05 07 2021
05 07 2021
Historique:
received:
04
11
2020
revised:
19
01
2021
accepted:
23
01
2021
pubmed:
15
2
2021
medline:
8
6
2021
entrez:
14
2
2021
Statut:
ppublish
Résumé
Melatonin (MEL) shows an anti-inflammatory effect and regulates intestinal microbiota communities in animals and humans; Ochratoxin A (OTA) induces liver inflammation through intestinal microbiota. However, it remains to know whether MEL alleviates the liver inflammation induced by OTA. In this study, MEL reversed various adverse effects induced by OTA. MEL recovered the swarming and motility of intestinal microbiota, decreased the accumulation of lipopolysaccharide (LPS), enhanced the tight junction proteins of jejunum and cecum segments; ultimately alleviated OTA-induced liver inflammation in ducks. However, it is worth noting that MEL still had positive effects on the OTA-exposed ducks after antibiotic treatment. These results suggest that both the maintenance of intestinal microbiota homeostasis and intestinal microbiota-independent manner involved the MEL anti-inflammatory function in OTA-induced liver inflammation. MEL represent a promising protective approach for OTA, even other mycotoxins.
Identifiants
pubmed: 33582472
pii: S0304-3894(21)00202-8
doi: 10.1016/j.jhazmat.2021.125239
pii:
doi:
Substances chimiques
Antioxidants
0
Ochratoxins
0
ochratoxin A
1779SX6LUY
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
125239Informations de copyright
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