Ghrelin as an Anti-Sepsis Peptide: Review.
anti-inflammation
cytokine storm
ghrelin
growth hormone
inflammation
sepsis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
09
2020
accepted:
09
12
2020
entrez:
15
2
2021
pubmed:
16
2
2021
medline:
23
6
2021
Statut:
epublish
Résumé
Sepsis continues to produce widespread inflammation, illness, and death, prompting intensive research aimed at uncovering causes and therapies. In this article, we focus on ghrelin, an endogenous peptide with promise as a potent anti-inflammatory agent. Ghrelin was discovered, tracked, and isolated from stomach cells based on its ability to stimulate release of growth hormone. It also stimulates appetite and is shown to be anti-inflammatory in a wide range of tissues. The anti-inflammatory effects mediated by ghrelin are a result of both the stimulation of anti-inflammatory processes and an inhibition of pro-inflammatory forces. Anti-inflammatory processes are promoted in a broad range of tissues including the hypothalamus and vagus nerve as well as in a broad range of immune cells. Aged rodents have reduced levels of growth hormone (GH) and diminished immune responses; ghrelin administration boosts GH levels and immune response. The anti-inflammatory functions of ghrelin, well displayed in preclinical animal models of sepsis, are just being charted in patients, with expectations that ghrelin and growth hormone might improve outcomes in patients with sepsis.
Identifiants
pubmed: 33584688
doi: 10.3389/fimmu.2020.610363
pmc: PMC7876230
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Cytokines
0
Ghrelin
0
Inflammation Mediators
0
Receptors, Ghrelin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
610363Informations de copyright
Copyright © 2021 Mathur, Mehdi, Anipindi, Aziz, Khan, Kondakindi, Lowell, Wang and Roth.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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