A DNA-Encoded Chemical Library Based on Peptide Macrocycles.
DNA encoded chemical libraries
NKp46
carbonic anhydrases
macrocycles
serum albumins
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
26 Apr 2021
26 Apr 2021
Historique:
received:
21
12
2020
pubmed:
16
2
2021
medline:
30
4
2021
entrez:
15
2
2021
Statut:
ppublish
Résumé
The synthesis and characterization of a novel DNA-encoded library of macrocyclic peptide derivatives are described; the macrocycles are based on three sets of proteinogenic and non-proteinogenic amino acid building blocks and featuring the use of copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reaction for ring closure. The library (termed YO-DEL) which contains 1 254 838 compounds, was encoded with DNA in single-stranded format and was screened against target proteins of interest using affinity capture procedures and photocrosslinking. YO-DEL selections yielded specific binders against serum albumins, carbonic anhydrases and NKp46, a marker of activated Natural Killer cells.
Identifiants
pubmed: 33586277
doi: 10.1002/chem.202005423
doi:
Substances chimiques
Peptides
0
Small Molecule Libraries
0
DNA
9007-49-2
Carbonic Anhydrases
EC 4.2.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7160-7167Informations de copyright
© 2021 Wiley-VCH GmbH.
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