Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
07
06
2020
revised:
13
11
2020
accepted:
13
01
2021
pubmed:
17
2
2021
medline:
19
2
2022
entrez:
16
2
2021
Statut:
ppublish
Résumé
Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we combined FACS-based genome-wide CRISPR screens with a data-mining approach to identify drugs that can upregulate MHC-I without inducing PD-L1. CRISPR screening identified TRAF3, a suppressor of the NFκB pathway, as a negative regulator of MHC-I but not PD-L1. The
Identifiants
pubmed: 33589424
pii: 2159-8290.CD-20-0812
doi: 10.1158/2159-8290.CD-20-0812
pmc: PMC8543117
mid: NIHMS1666185
doi:
Substances chimiques
B7-H1 Antigen
0
Histocompatibility Antigens Class I
0
Immune Checkpoint Inhibitors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1524-1541Subventions
Organisme : NCI NIH HHS
ID : R01 CA234018
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA206963
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA101942
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG002295
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI137337
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
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