Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
28
01
2020
accepted:
13
01
2021
pubmed:
17
2
2021
medline:
24
4
2021
entrez:
16
2
2021
Statut:
ppublish
Résumé
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlights astrocytes as essential components for modulation of emotional states under normal and chronic pain conditions.
Identifiants
pubmed: 33589833
doi: 10.1038/s41593-021-00800-0
pii: 10.1038/s41593-021-00800-0
doi:
Substances chimiques
Receptors, Oxytocin
0
Oxytocin
50-56-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
529-541Subventions
Organisme : Intramural NIH HHS
ID : ZIA MH002498
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS094640
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL090948
Pays : United States
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