An organelle-tethering mechanism couples flagellation to cell division in bacteria.
Caulobacter crescentus
FlbD
FlhA
FliX
RpoN
alphaproteobacteria
bacterial motility
cell division
divisome
flagellar development
Journal
Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028
Informations de publication
Date de publication:
08 03 2021
08 03 2021
Historique:
received:
13
07
2020
revised:
09
12
2020
accepted:
20
01
2021
pubmed:
19
2
2021
medline:
31
8
2021
entrez:
18
2
2021
Statut:
ppublish
Résumé
In some free-living and pathogenic bacteria, problems in the synthesis and assembly of early flagellar components can cause cell-division defects. However, the mechanism that couples cell division with the flagellar biogenesis has remained elusive. Herein, we discover the regulator MadA that controls transcription of flagellar and cell-division genes in Caulobacter crescentus. We demonstrate that MadA, a small soluble protein, binds the type III export component FlhA to promote activation of FliX, which in turn is required to license the conserved σ
Identifiants
pubmed: 33600766
pii: S1534-5807(21)00071-X
doi: 10.1016/j.devcel.2021.01.013
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
657-670.e4Subventions
Organisme : Wellcome Trust
ID : 500140/Z/09/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT101885MA
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.