Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders.
Affect
Alcohol-Related Disorders
/ metabolism
Androgens
/ metabolism
Dehydroepiandrosterone
/ metabolism
Estradiol
/ metabolism
Female
Humans
Male
Neurosteroids
/ metabolism
Pregnanolone
/ metabolism
Progesterone
/ metabolism
Progestins
/ metabolism
Sex Factors
Stress Disorders, Traumatic
/ metabolism
Testosterone
/ metabolism
Alcohol
Androgen-derived
Neurosteroids
Progestogen-derived
Sex differences
Stress-related disorders
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
15
11
2020
revised:
04
02
2021
accepted:
11
02
2021
pubmed:
19
2
2021
medline:
15
12
2021
entrez:
18
2
2021
Statut:
ppublish
Résumé
Stress and trauma exposure disturbs stress regulation systems and thus increases the vulnerability for stress-related disorders which are characterized by negative affect, including major depressive disorder, anxiety disorders and posttraumatic stress disorder. Similarly, stress and trauma exposure results in increased vulnerability to problematic alcohol use and alcohol use disorder, especially among women, who are more likely to drink to cope with negative affect than their male counterparts. Given these associations, the relationship between stress-related disorders and alcohol use is generally stronger among women leading to complex comorbidities across these disorders and alcohol misuse. This review highlights the therapeutic potential for progestogen- and androgen-derived neurosteroids, which affect both stress- and alcohol-related disorders, to target the overlapping symptoms related to negative affect. This article is part of the special issue on 'Vulnerabilities to Substance Abuse.'
Identifiants
pubmed: 33600842
pii: S0028-3908(21)00053-8
doi: 10.1016/j.neuropharm.2021.108499
pmc: PMC7992136
mid: NIHMS1678358
pii:
doi:
Substances chimiques
Androgens
0
Neurosteroids
0
Progestins
0
Testosterone
3XMK78S47O
Dehydroepiandrosterone
459AG36T1B
Progesterone
4G7DS2Q64Y
Estradiol
4TI98Z838E
Pregnanolone
BXO86P3XXW
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108499Subventions
Organisme : NIMH NIH HHS
ID : R01 MH110674
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIAAA NIH HHS
ID : P01 AA027473
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA033945
Pays : United States
Organisme : NIAAA NIH HHS
ID : U54 AA027989
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01 AA025670
Pays : United States
Organisme : NIAAA NIH HHS
ID : R03 AA028361
Pays : United States
Informations de copyright
Published by Elsevier Ltd.
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