Structural characterization of fondaparinux interaction with per-6-amino-beta-cyclodextrin: An NMR and MS study.

Fondaparinux Heparin Magnetic Resonance Spectroscopy beta-Cyclodextrins
Antidote Degradation Electrostatic interaction Heparin NMR

Journal

Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336

Informations de publication

Date de publication:
15 Apr 2021
Historique:
received: 16 10 2020
revised: 28 01 2021
accepted: 30 01 2021
pubmed: 19 2 2021
medline: 22 6 2021
entrez: 18 2 2021
Statut: ppublish

Résumé

The highly anionic synthetic pentasaccharide fondaparinux (FDPX) - representing the antithrombin binding sequence of heparin - is in clinical use as a potent anticoagulant. Contrary to the unfractionated heparin, FDPX lacks potent antidote completely reversing its anticoagulant activity, therefore it is of great importance to identify new structures exhibiting strong intermolecular interactions towards FDPX. The polycationic heptakis(6-amino-6-deoxy)-beta-cyclodextrin (NH

Identifiants

DOI: 10.1016/j.jpba.2021.113947 PMID: 33601159
pubmed: 33601159
pii: S0731-7085(21)00059-5
doi: 10.1016/j.jpba.2021.113947
pii:
doi:

Substances chimiques

beta-Cyclodextrins 0
per-6-amino-beta-cyclodextrin 0
Heparin 9005-49-6
Fondaparinux J177FOW5JL

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113947

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Bianka Várnai (B)

Semmelweis University, Department of Pharmacognosy, Üllői út. 26, H-1085, Budapest, Hungary.

Márkó Grabarics (M)

Freie Universität Berlin, Institute of Chemistry and Biochemistry, Arnimallee 22, 14195, Berlin, Germany; Fritz Haber Institute of the Max Planck Society, Department of Molecular Physics, Faradayweg 4-6, 14195, Berlin, Germany.

Zoltán Szakács (Z)

Gedeon Richter Plc., Spectroscopic Research Department, H-1475, Budapest, P.O.B. 27, Hungary.

Kevin Pagel (K)

Freie Universität Berlin, Institute of Chemistry and Biochemistry, Arnimallee 22, 14195, Berlin, Germany; Fritz Haber Institute of the Max Planck Society, Department of Molecular Physics, Faradayweg 4-6, 14195, Berlin, Germany.

Milo Malanga (M)

CycloLab, Cyclodextrin R&D Ltd, Budapest, H-1097, Illatos út 7, Hungary.

Tamás Sohajda (T)

CycloLab, Cyclodextrin R&D Ltd, Budapest, H-1097, Illatos út 7, Hungary.

Szabolcs Béni (S)

Semmelweis University, Department of Pharmacognosy, Üllői út. 26, H-1085, Budapest, Hungary. Electronic address: beni.szabolcs@pharma.semmelweis-univ.hu.

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Classifications MeSH

questionsmedicales.fr › Glucides › Polyosides › Oligosaccharides › Fondaparinux › Structural characterization of fondaparinux...
questionsmedicales.fr › Glucides › Polyosides › Glycosaminoglycanes › Héparine › Structural characterization of fondaparinux...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Structural characterization of fondaparinux...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Amidon › Dextrine › Cyclodextrines › Cyclodextrines bêta › Structural characterization of fondaparinux...