Meiosis and beyond - understanding the mechanistic and evolutionary processes shaping the germline genome.
DNA repair
double-strand breaks
mutation hotspots
mutation rate
recombination
recombination hotspots
selection
Journal
Biological reviews of the Cambridge Philosophical Society
ISSN: 1469-185X
Titre abrégé: Biol Rev Camb Philos Soc
Pays: England
ID NLM: 0414576
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
15
12
2020
received:
26
11
2019
accepted:
15
12
2020
pubmed:
23
2
2021
medline:
26
10
2021
entrez:
22
2
2021
Statut:
ppublish
Résumé
The separation of germ cell populations from the soma is part of the evolutionary transition to multicellularity. Only genetic information present in the germ cells will be inherited by future generations, and any molecular processes affecting the germline genome are therefore likely to be passed on. Despite its prevalence across taxonomic kingdoms, we are only starting to understand details of the underlying micro-evolutionary processes occurring at the germline genome level. These include segregation, recombination, mutation and selection and can occur at any stage during germline differentiation and mitotic germline proliferation to meiosis and post-meiotic gamete maturation. Selection acting on germ cells at any stage from the diploid germ cell to the haploid gametes may cause significant deviations from Mendelian inheritance and may be more widespread than previously assumed. The mechanisms that affect and potentially alter the genomic sequence and allele frequencies in the germline are pivotal to our understanding of heritability. With the rise of new sequencing technologies, we are now able to address some of these unanswered questions. In this review, we comment on the most recent developments in this field and identify current gaps in our knowledge.
Identifiants
pubmed: 33615674
doi: 10.1111/brv.12680
pmc: PMC8246768
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
822-841Informations de copyright
© 2021 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society.
Références
Cell. 2014 Aug 14;158(4):861-873
pubmed: 25126790
Trends Cell Biol. 2012 May;22(5):241-9
pubmed: 22480579
Mol Cell. 2013 Aug 22;51(4):440-53
pubmed: 23973374
Hum Reprod. 2009 Aug;24(8):1946-59
pubmed: 19395363
Hum Mutat. 2014 Nov;35(11):1280-4
pubmed: 25136821
Annu Rev Plant Physiol Plant Mol Biol. 1998 Jun;49:371-395
pubmed: 15012239
Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1588-93
pubmed: 26811451
Nat Rev Genet. 2012 Oct;13(10):745-53
pubmed: 22965354
Genetics. 2002 Dec;162(4):1837-47
pubmed: 12524353
Nat Cell Biol. 2011 May;13(5):599-610
pubmed: 21478856
Genetics. 2018 Feb;208(2):435-471
pubmed: 29378808
Curr Biol. 2018 Apr 23;28(8):1289-1295.e4
pubmed: 29606420
Biol Reprod. 1971 Apr;4(2):195-215
pubmed: 4107186
Nat Ecol Evol. 2019 Feb;3(2):286-292
pubmed: 30664699
Science. 2009 Oct 9;326(5950):289-93
pubmed: 19815776
Nature. 1989 Mar 2;338(6210):35-9
pubmed: 2537472
Nat Plants. 2017 Dec;3(12):926-929
pubmed: 29209081
PLoS Genet. 2013 Jun;9(6):e1003545
pubmed: 23825959
BMC Genomics. 2011 Feb 09;12:101
pubmed: 21306613
PLoS Genet. 2010 Mar 05;6(3):e1000868
pubmed: 20221264
Nature. 2017 Sep 28;549(7673):519-522
pubmed: 28959963
Ann N Y Acad Sci. 2017 Feb;1389(1):164-185
pubmed: 27997700
Annu Rev Genet. 2003;37:393-408
pubmed: 14616067
Philos Trans R Soc Lond B Biol Sci. 2017 Dec 19;372(1736):
pubmed: 29109219
Genetics. 2012 Sep;192(1):33-53
pubmed: 22964836
Genome Biol Evol. 2016 Dec 1;8(12):3815-3821
pubmed: 28173099
Genes Cells. 2014 May;19(5):359-73
pubmed: 24635992
Genes Dev. 2016 Feb 1;30(3):266-80
pubmed: 26833728
Genome Biol. 2018 Nov 19;19(1):199
pubmed: 30454069
Nat Rev Genet. 2011 Aug 18;12(9):615-27
pubmed: 21850042
Cell. 2017 Mar 9;168(6):977-989.e17
pubmed: 28262352
Mol Biol Evol. 2012 Aug;29(8):1907-16
pubmed: 22328716
Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12592-7
pubmed: 15299144
Genetics. 2012 Jul;191(3):757-64
pubmed: 22562932
Proc Natl Acad Sci U S A. 1990 Jun;87(12):4692-6
pubmed: 2352943
Open Biol. 2013 Jul 31;3(7):130019
pubmed: 23902647
Nature. 2013 Sep 19;501(7467):416-20
pubmed: 23975097
Cell. 1997 Sep 19;90(6):1123-35
pubmed: 9323140
Genetics. 2001 Jul;158(3):1013-25
pubmed: 11454751
Theor Appl Genet. 1975 Jan;46(6):277-80
pubmed: 24420121
Cell. 2019 Aug 22;178(5):1132-1144.e10
pubmed: 31402175
Hum Mutat. 2012 Nov;33(11):1599-609
pubmed: 22837079
Genes Dev. 2009 Dec 1;23(23):2705-10
pubmed: 19952105
Trends Genet. 2004 Jul;20(7):314-9
pubmed: 15219396
PLoS One. 2009 Oct 08;4(10):e7386
pubmed: 19812694
Nat Commun. 2019 Oct 22;10(1):4795
pubmed: 31641121
Mol Biol Evol. 2016 Feb;33(2):554-67
pubmed: 26541172
Science. 2005 Oct 14;310(5746):321-4
pubmed: 16224025
Nature. 2011 Oct 16;479(7372):237-40
pubmed: 22002603
Cell. 2014 Dec 18;159(7):1665-80
pubmed: 25497547
Genetics. 2003 May;164(1):81-94
pubmed: 12750322
Trends Genet. 2007 Feb;23(2):91-9
pubmed: 17208327
Genome Biol. 2010;11(2):104
pubmed: 20210982
BMC Biol. 2018 Jul 5;16(1):72
pubmed: 29973198
Cell. 1993 Feb 26;72(4):595-605
pubmed: 7679954
Genome Res. 2001 Nov;11(11):1854-60
pubmed: 11691850
Biol Reprod. 2001 Jun;64(6):1730-8
pubmed: 11369602
Genes Cells. 2019 Jan;24(1):6-30
pubmed: 30479058
Cell. 1985 Mar;40(3):491-500
pubmed: 2982495
Annu Rev Plant Biol. 2015;66:297-327
pubmed: 25494464
Curr Opin Genet Dev. 2002 Dec;12(6):650-6
pubmed: 12433577
Biol Res. 2010;43(3):275-85
pubmed: 21249298
Nat Genet. 2004 Jul;36(7):700-6
pubmed: 15184900
Genes Dev. 2004 Jan 15;18(2):117-25
pubmed: 14752007
EMBO J. 2009 Jan 21;28(2):99-111
pubmed: 19078966
Philos Trans R Soc Lond B Biol Sci. 2016 Oct 19;371(1706):
pubmed: 27619705
Nat Rev Genet. 2013 Nov;14(11):794-806
pubmed: 24136506
Cell. 2011 Mar 4;144(5):719-31
pubmed: 21376234
Nat Struct Mol Biol. 2019 Mar;26(3):164-174
pubmed: 30778236
Nat Genet. 2015 Jul;47(7):727-735
pubmed: 25985139
Annu Rev Genomics Hum Genet. 2009;10:285-311
pubmed: 19630562
Genome Res. 2014 Oct;24(10):1650-64
pubmed: 25024163
Mol Biol Evol. 2017 Sep 1;34(9):2163-2172
pubmed: 28645195
Nat Commun. 2017 Aug 21;8(1):303
pubmed: 28827725
Exp Cell Res. 2014 Nov 15;329(1):124-31
pubmed: 25116420
Genetica. 1998;102-103(1-6):507-24
pubmed: 9766963
Free Radic Biol Med. 2015 Dec;89:993-1002
pubmed: 26510519
Ann Eugen. 1947 Jun;13(4):262-71
pubmed: 20249869
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10471-6
pubmed: 18650392
Cell. 2010 Dec 10;143(6):924-37
pubmed: 21145459
Cell. 2006 Jun 30;125(7):1321-32
pubmed: 16814718
Nat Rev Genet. 2009 Oct;10(10):691-703
pubmed: 19763152
Genome Biol. 2015 Apr 14;16:77
pubmed: 25886366
Philos Trans R Soc Lond B Biol Sci. 2017 Dec 19;372(1736):
pubmed: 29109228
PLoS Genet. 2014 Nov 13;10(11):e1004790
pubmed: 25393762
Trends Genet. 2019 May;35(5):359-370
pubmed: 30948240
Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4110-5
pubmed: 26979956
Annu Rev Genet. 2012;46:651-75
pubmed: 23145912
Int J Mol Sci. 2015 Dec 16;16(12):29923-35
pubmed: 26694360
Environ Epigenet. 2016 Aug 27;2(3):dvw015
pubmed: 29492295
Mol Cell. 1998 Aug;2(2):267-73
pubmed: 9734365
Nat Commun. 2019 Feb 27;10(1):970
pubmed: 30814509
Chromosome Res. 2007;15(5):565-77
pubmed: 17674146
Nature. 2014 Jun 12;510(7504):241-6
pubmed: 24717437
Int J Biochem Cell Biol. 2018 May;98:24-28
pubmed: 29474927
Nat Commun. 2017 May 09;8:15183
pubmed: 28485371
J Cell Biol. 2011 Oct 31;195(3):359-67
pubmed: 22024169
Nat Commun. 2019 Mar 5;10(1):1054
pubmed: 30837461
J Cell Biol. 2014 Jun 9;205(5):633-41
pubmed: 24891606
Cell. 2006 Apr 21;125(2):315-26
pubmed: 16630819
Am J Hum Genet. 2006 Jul;79(1):41-53
pubmed: 16773564
Mol Biol Evol. 2006 Jun;23(6):1203-16
pubmed: 16551647
Nat Rev Genet. 2009 Feb;10(2):94-108
pubmed: 19148191
Nature. 2005 Oct 27;437(7063):1299-320
pubmed: 16255080
Mol Cell. 2015 Mar 5;57(5):797-811
pubmed: 25661491
G3 (Bethesda). 2013 Oct 03;3(10):1741-51
pubmed: 23979930
Science. 2019 Jan 25;363(6425):
pubmed: 30679340
PLoS Biol. 2011 Dec;9(12):e1001211
pubmed: 22162947
Nature. 2002 May 16;417(6886):227
pubmed: 12015578
Am J Hum Genet. 2011 Oct 7;89(4):580-8
pubmed: 21981782
Genome Res. 2018 Apr;28(4):532-546
pubmed: 29530928
Hum Mol Genet. 2016 Feb 1;25(3):484-96
pubmed: 26614388
Sci Rep. 2017 Jan 31;7:41585
pubmed: 28139771
PLoS Biol. 2016 Jan 13;14(1):e1002355
pubmed: 26761240
PLoS Genet. 2016 Oct 28;12(10):e1006389
pubmed: 27792785
Chromosome Res. 2001;9(7):541-67
pubmed: 11721953
Exp Cell Res. 1995 Aug;219(2):604-11
pubmed: 7641811
Science. 2017 Nov 3;358(6363):668-672
pubmed: 29097549
Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6075-80
pubmed: 18417451
Nat Protoc. 2016 Jul;11(7):1229-43
pubmed: 27310263
PLoS Genet. 2009 Dec;5(12):e1000753
pubmed: 19997497
Nature. 2020 Feb;578(7793):94-101
pubmed: 32025018
Curr Biol. 2014 Oct 6;24(19):2295-300
pubmed: 25242031
Cell Rep. 2018 Jun 26;23(13):3920-3932
pubmed: 29949774
Sci Rep. 2015 Jul 28;5:12281
pubmed: 26216318
Mol Cell. 2019 Feb 7;73(3):547-561.e6
pubmed: 30735655
Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2407-11
pubmed: 2006178
Cell Cycle. 2016;15(1):13-21
pubmed: 26730703
Bioessays. 2011 Dec;33(12):938-45
pubmed: 22006834
Nat Genet. 2016 Feb;48(2):126-133
pubmed: 26656846
PLoS Biol. 2020 Aug 17;18(8):e3000838
pubmed: 32804933
Genome Res. 2017 Feb;27(2):278-288
pubmed: 27923845
Cell. 2017 Jul 13;170(2):367-381.e20
pubmed: 28709003
Nature. 2009 Jul 23;460(7254):473-8
pubmed: 19525931
Nat Cell Biol. 2017 Sep;19(9):1071-1080
pubmed: 28825700
Elife. 2017 Jun 16;6:
pubmed: 28621664
Nature. 2010 Oct 28;467(7319):1099-103
pubmed: 20981099
Nature. 2017 Apr 6;544(7648):110-114
pubmed: 28355183
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4424-9
pubmed: 11930003
Cell. 2012 Jul 20;150(2):402-12
pubmed: 22817899
Cold Spring Harb Symp Quant Biol. 2017;82:235-247
pubmed: 29743337
Curr Opin Genet Dev. 2020 Jun;62:58-64
pubmed: 32634682
Trends Biochem Sci. 2006 Apr;31(4):206-14
pubmed: 16545956
Hum Mol Genet. 2006 Apr 1;15(7):1099-111
pubmed: 16501000
Anim Reprod Sci. 2014 Sep;149(1-2):3-10
pubmed: 25028181
Am J Hum Genet. 2012 Feb 10;90(2):175-200
pubmed: 22325359
Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6857-61
pubmed: 9192656
PLoS Genet. 2013 Aug;9(8):e1003732
pubmed: 24009525
Genetics. 2003 Feb;163(2):811-22
pubmed: 12618416
Cell Rep. 2017 Feb 7;18(6):1366-1382
pubmed: 28178516
J Vis Exp. 2018 Feb 26;(132):
pubmed: 29553540
Genome Biol Evol. 2016 Aug 25;8(8):2442-51
pubmed: 27401172
Bioinformatics. 2017 Dec 01;33(23):3726-3732
pubmed: 29036272
Chromosoma. 2018 Sep;127(3):341-359
pubmed: 29582139
Hereditas. 1990;112(3):265-70
pubmed: 2211180
Mob DNA. 2016 Aug 11;7:16
pubmed: 27525044
Genome Res. 2009 May;19(5):770-7
pubmed: 19342477
Nat Genet. 1998 Oct;20(2):116-7
pubmed: 9771701
PLoS Biol. 2007 Nov 6;5(11):e292
pubmed: 17988172
Biol Reprod. 2008 Feb;78(2):324-32
pubmed: 18032420
Nat Genet. 2019 Jan;51(1):36-41
pubmed: 30510240
PLoS Genet. 2013;9(12):e1003978
pubmed: 24367271
Bioessays. 2014 Feb 26;36(4):382-393
pubmed: 24615916
Nat Ecol Evol. 2020 May;4(5):737-744
pubmed: 32203473
Int J Mol Sci. 2018 Dec 21;20(1):
pubmed: 30577615
Genetics. 2002 Mar;160(3):1011-22
pubmed: 11901118
Nature. 2020 Jun;582(7810):124-128
pubmed: 32494071
Cell. 2013 Dec 19;155(7):1492-506
pubmed: 24360273
Hum Mol Genet. 2000 Mar 22;9(5):725-33
pubmed: 10749979
Genetics. 1987 Oct;117(2):331-41
pubmed: 3666445
Nature. 2015 Apr 2;520(7545):114-8
pubmed: 25539084
Nature. 2014 Jul 31;511(7511):551-6
pubmed: 25043020
Front Plant Sci. 2016 Sep 22;7:1433
pubmed: 27713757
Genetics. 2017 Sep;207(1):255-267
pubmed: 28733365
Cell. 2016 Jan 28;164(3):538-49
pubmed: 26806129
Nat Struct Mol Biol. 2019 Mar;26(3):175-184
pubmed: 30778237
PLoS Genet. 2014 Mar 06;10(3):e1004195
pubmed: 24603440
Elife. 2017 Jun 06;6:
pubmed: 28590247
Nat Struct Mol Biol. 2010 Jun;17(6):679-87
pubmed: 20473313
Cell. 2018 May 3;173(4):839-850.e18
pubmed: 29628142
Elife. 2017 Apr 25;6:
pubmed: 28440220
Nature. 2015 Jun 11;522(7555):221-5
pubmed: 25896322
Asian J Androl. 2011 Jul;13(4):620-1
pubmed: 21532603
Curr Biol. 2019 Nov 4;29(21):3692-3698.e4
pubmed: 31630954
Annu Rev Genet. 1995;29:423-44
pubmed: 8825482
Mol Biol Evol. 2013 Jun;30(6):1409-19
pubmed: 23505044
Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9730-5
pubmed: 17535928
Nat Commun. 2019 Sep 6;10(1):4053
pubmed: 31492841
Cell Cycle. 2012 Apr 15;11(8):1496-503
pubmed: 22433953
Proc Biol Sci. 2007 Jan 7;274(1606):1-10
pubmed: 17134994
Trends Genet. 2004 Oct;20(10):464-7
pubmed: 15363897
Elife. 2015 Dec 15;4:e11389
pubmed: 26670547
Curr Opin Genet Dev. 2009 Apr;19(2):99-104
pubmed: 19327980
Hum Mol Genet. 2013 Oct 15;22(20):4117-26
pubmed: 23740942
Nature. 1998 Dec 24-31;396(6713):743-6
pubmed: 9874369
Bioessays. 2018 Jun;40(6):e1700189
pubmed: 29709066
Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6368-73
pubmed: 18434551
Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8053-8058
pubmed: 28698378
Cell. 2008 Mar 7;132(5):758-70
pubmed: 18329363
PLoS Biol. 2005 Mar;3(3):e63
pubmed: 15736976
Genome Res. 2002 Jul;12(7):1075-9
pubmed: 12097344
Nat Commun. 2019 Sep 20;10(1):4309
pubmed: 31541091
Cell. 2020 Jan 23;180(2):248-262.e21
pubmed: 31978344
PLoS Genet. 2018 Aug 30;14(8):e1007479
pubmed: 30161134
Genetics. 1991 Dec;129(4):1167-76
pubmed: 1783297
Fertil Steril. 2010 Apr;93(6):1903-6
pubmed: 20152966
Nucleic Acids Res. 2017 Sep 19;45(16):9481-9502
pubmed: 28934495
PLoS Genet. 2012;8(2):e1002535
pubmed: 22359519
Philos Trans R Soc Lond B Biol Sci. 2017 Dec 19;372(1736):
pubmed: 29109221
Genetics. 1989 Sep;123(1):191-7
pubmed: 2806882
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9491-9500
pubmed: 31019089
Genes Dev. 2008 Feb 1;22(3):398-410
pubmed: 18245451
Andrology. 2019 Jul;7(4):516-526
pubmed: 31119900
Genetics. 1999 Oct;153(2):607-20
pubmed: 10511543
Mol Biol Evol. 2013 Nov;30(11):2475-86
pubmed: 23997108
Cold Spring Harb Perspect Biol. 2015 Jan 20;7(5):
pubmed: 25605710
Bioessays. 2016 Nov;38(11):1158-1166
pubmed: 27604404
Genetics. 2010 Jul;185(3):771-82
pubmed: 20421598
Am Nat. 2018 Aug;192(2):241-249
pubmed: 30016160
Cell Mol Life Sci. 2018 Aug;75(15):2859-2872
pubmed: 29417179
Theor Popul Biol. 2019 Apr;126:19-32
pubmed: 30660607
Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5635-E5644
pubmed: 28630288
Genome Biol. 2018 Jul 30;19(1):101
pubmed: 30060743
Cytogenet Genome Res. 2015;147(2-3):81-94
pubmed: 26730606
J Biol Chem. 1989 Nov 25;264(33):20120-30
pubmed: 2684969
J Exp Bot. 2003 Jan;54(380):11-23
pubmed: 12456751
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5280-5
pubmed: 12682288
Philos Trans R Soc Lond B Biol Sci. 2011 Aug 12;366(1575):2266-73
pubmed: 21727132