Deficiency of Endothelial CD40 Induces a Stable Plaque Phenotype and Limits Inflammatory Cell Recruitment to Atherosclerotic Lesions in Mice.
Animals
Aorta
/ immunology
Aortic Diseases
/ genetics
Apoptosis
Atherosclerosis
/ genetics
CD40 Antigens
/ deficiency
Cell Adhesion
Cells, Cultured
Chemotaxis, Leukocyte
Coculture Techniques
Disease Models, Animal
Endothelial Cells
/ immunology
Humans
Intercellular Adhesion Molecule-1
/ metabolism
Macrophages
/ immunology
Male
Mice, Knockout, ApoE
Monocytes
/ immunology
Plaque, Atherosclerotic
Signal Transduction
Vascular Cell Adhesion Molecule-1
/ metabolism
Journal
Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
aheadofprint:
22
02
2021
pubmed:
23
2
2021
medline:
11
3
2022
entrez:
22
2
2021
Statut:
ppublish
Résumé
The co-stimulatory CD40L-CD40 dyad exerts a critical role in atherosclerosis by modulating leukocyte accumulation into developing atherosclerotic plaques. The requirement for cell-type specific expression of both molecules, however, remains elusive. Here, we evaluate the contribution of CD40 expressed on endothelial cells (ECs) in a mouse model of atherosclerosis. Atherosclerotic plaques of apolipoprotein E-deficient ( Endothelial deficiency of CD40 in mice promotes structural features associated with a stable plaque phenotype in humans and decreases leukocyte adhesion. These results suggest that endothelial-expressed CD40 contributes to inflammatory cell migration and consecutive plaque formation in atherogenesis.
Substances chimiques
CD40 Antigens
0
Vascular Cell Adhesion Molecule-1
0
Intercellular Adhesion Molecule-1
126547-89-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1530-1540Subventions
Organisme : 366904753
ID : German Research Foundation
Organisme : 81X2800139
ID : German Center for Cardiovascular Research
Organisme : 853425
ID : European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program
Organisme : MOTI-VATE scholarship
ID : Forschungskomission of the University of Freiburg
Organisme : Kaltenbach scholarship
ID : Else Kröner-Fresenius-Stiftung
Organisme : Berta-Ottenstein-Program for Advanced Clinician Scientists
ID : Deutsche Herzstiftung
Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
L. F., P. S., L. S. M., J. M., C. W., I. H., C. v. z. M., C. B., and D. W. are members of the Collaborative Research Centre SFB1425 of the German Research Foundation.