Telomere length is associated with HIV infection, methamphetamine use, inflammation, and comorbid disease risk.
Aging
Cardiovascular
HIV
Methamphetamine
Telomeres
Journal
Drug and alcohol dependence
ISSN: 1879-0046
Titre abrégé: Drug Alcohol Depend
Pays: Ireland
ID NLM: 7513587
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
01
11
2020
revised:
17
01
2021
accepted:
01
02
2021
pubmed:
24
2
2021
medline:
29
6
2021
entrez:
23
2
2021
Statut:
ppublish
Résumé
HIV infection and methamphetamine dependence (METH) are each associated with inflammation and premature aging, but their impact on biological aging is difficult to measure. Here we examined the impact of HIV and METH on leukocyte telomere lengths (LTL), and the correlations between LTL and other aging biomarkers. The study was a cross-sectional analysis of 161 individuals categorized by HIV and methamphetamine (METH) dependence status into four groups: HIV-METH- (n = 50), HIV-METH+ (n = 29), HIV + METH- (n = 40), and HIV + METH+ (n = 42). We analyzed the relationships of leukocyte telomere length (telomere to single copy gene [T/S] ratio) with demographic and clinical data as well as a panel of biomarkers of inflammation and endothelial activation measured in blood and cerebrospinal fluid (CSF). HIV and METH were independently associated with shorter T/S ratio, even after adjusting for demographics and leukocyte count (R HIV and METH dependence were each associated with shorter telomeres. After adjusting for demographics, HIV, and METH, T/S ratio remained associated with aging-related outcomes including neurocognitive impairment, neurodegeneration, risks of cardiovascular disease and stroke. While not establishing causality, this study supports using the T/S ratio as a biomarker for estimating the impact of HIV and comorbidities on long-term health.
Sections du résumé
BACKGROUND
HIV infection and methamphetamine dependence (METH) are each associated with inflammation and premature aging, but their impact on biological aging is difficult to measure. Here we examined the impact of HIV and METH on leukocyte telomere lengths (LTL), and the correlations between LTL and other aging biomarkers.
METHODS
The study was a cross-sectional analysis of 161 individuals categorized by HIV and methamphetamine (METH) dependence status into four groups: HIV-METH- (n = 50), HIV-METH+ (n = 29), HIV + METH- (n = 40), and HIV + METH+ (n = 42). We analyzed the relationships of leukocyte telomere length (telomere to single copy gene [T/S] ratio) with demographic and clinical data as well as a panel of biomarkers of inflammation and endothelial activation measured in blood and cerebrospinal fluid (CSF).
RESULTS
HIV and METH were independently associated with shorter T/S ratio, even after adjusting for demographics and leukocyte count (R
CONCLUSIONS
HIV and METH dependence were each associated with shorter telomeres. After adjusting for demographics, HIV, and METH, T/S ratio remained associated with aging-related outcomes including neurocognitive impairment, neurodegeneration, risks of cardiovascular disease and stroke. While not establishing causality, this study supports using the T/S ratio as a biomarker for estimating the impact of HIV and comorbidities on long-term health.
Identifiants
pubmed: 33621803
pii: S0376-8716(21)00134-4
doi: 10.1016/j.drugalcdep.2021.108639
pmc: PMC8026664
mid: NIHMS1674256
pii:
doi:
Substances chimiques
Biomarkers
0
Inflammation Mediators
0
Methamphetamine
44RAL3456C
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
108639Subventions
Organisme : NIMH NIH HHS
ID : K24 MH097673
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA026306
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA047879
Pays : United States
Organisme : NIMH NIH HHS
ID : P30 MH062512
Pays : United States
Organisme : NIA NIH HHS
ID : F31 AG064989
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI036214
Pays : United States
Organisme : NIDA NIH HHS
ID : K23 DA037793
Pays : United States
Informations de copyright
Published by Elsevier B.V.
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