Mitochondrial hydrogen sulfide supplementation improves health in the
Animals
Caenorhabditis elegans
/ genetics
Caenorhabditis elegans Proteins
/ genetics
DNA-Binding Proteins
/ genetics
Dystrophin
/ deficiency
Forkhead Transcription Factors
/ genetics
Gene Expression Regulation
Humans
Hydrogen Sulfide
/ metabolism
Locomotion
/ drug effects
Male
Mice
Mice, Inbred mdx
Mitochondria, Muscle
/ drug effects
Mitogen-Activated Protein Kinases
/ genetics
Morpholines
/ metabolism
Muscle, Skeletal
/ drug effects
Muscular Dystrophy, Animal
/ drug therapy
Muscular Dystrophy, Duchenne
/ drug therapy
Organophosphorus Compounds
/ metabolism
Organothiophosphorus Compounds
/ metabolism
Prednisone
/ pharmacology
Sirtuins
/ genetics
Thiones
/ metabolism
Transcription Factors
/ genetics
Utrophin
/ deficiency
C. elegans
hydrogen sulfide
mitochondria
mouse
muscle
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
02 03 2021
02 03 2021
Historique:
entrez:
25
2
2021
pubmed:
26
2
2021
medline:
5
8
2021
Statut:
ppublish
Résumé
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscle degeneration and weakness due to mutations in the dystrophin gene. The symptoms of DMD share similarities with those of accelerated aging. Recently, hydrogen sulfide (H
Identifiants
pubmed: 33627403
pii: 2018342118
doi: 10.1073/pnas.2018342118
pmc: PMC7936346
pii:
doi:
Substances chimiques
AP39 compound
0
Caenorhabditis elegans Proteins
0
DNA-Binding Proteins
0
Dystrophin
0
Forkhead Transcription Factors
0
GYY 4137
0
Morpholines
0
Organophosphorus Compounds
0
Organothiophosphorus Compounds
0
Thiones
0
Transcription Factors
0
Utrophin
0
daf-16 protein, C elegans
0
dys-1 protein, C elegans
0
skn-1 protein, C elegans
148733-36-2
JNK-1 protein, C elegans
EC 2.7.11.24
Mitogen-Activated Protein Kinases
EC 2.7.11.24
SIR-2.1 protein, C elegans
EC 3.5.1.-
Sirtuins
EC 3.5.1.-
Prednisone
VB0R961HZT
Hydrogen Sulfide
YY9FVM7NSN
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S002626/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P021220/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_16072
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N015894/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P021220/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T026014/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K00414X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R502364/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: M.W., R.T., and the University of Exeter have intellectual property (patents awarded and pending) on slow-release sulfide-generating molecules and their therapeutic use. S.A.V. is an equity holder in NemaLife Inc.
Références
Physiol Rev. 2002 Apr;82(2):291-329
pubmed: 11917091
Antioxid Redox Signal. 2012 Jul 1;17(1):45-57
pubmed: 22229673
Hum Mol Genet. 2020 Jun 27;29(10):1607-1623
pubmed: 32227114
J Neurosci Methods. 2016 May 1;264:40-46
pubmed: 26947253
Free Radic Biol Med. 2015 Nov;88(Pt B):290-301
pubmed: 26232625
Neurology. 1978 May;28(5):439-46
pubmed: 76996
FASEB J. 2019 Aug;33(8):9540-9550
pubmed: 31162948
Steroids. 2002 Jul;67(8):715-9
pubmed: 12117619
J Cell Physiol. 2008 Mar;214(3):721-9
pubmed: 17894411
Cell. 1997 Aug 22;90(4):729-38
pubmed: 9288752
Biofizika. 2012 Nov-Dec;57(6):1014-9
pubmed: 23272582
Hum Mol Genet. 2015 Nov 15;24(22):6428-45
pubmed: 26358775
PLoS Genet. 2009 Dec;5(12):e1000780
pubmed: 20019812
J Endocrinol. 2014 Dec;223(3):R49-62
pubmed: 25271217
Indian J Occup Environ Med. 2007 May;11(2):56-60
pubmed: 21938216
J Mol Biol. 2006 Apr 28;358(2):387-95
pubmed: 16527307
Hum Mutat. 2015 Apr;36(4):395-402
pubmed: 25604253
Br Med J. 1980 Nov 29;281(6253):1461
pubmed: 7437838
Free Radic Biol Med. 2011 Jan 1;50(1):196-205
pubmed: 21034811
J Vis Exp. 2016 Dec 7;(118):
pubmed: 28060275
Dis Model Mech. 2015 Mar;8(3):195-213
pubmed: 25740330
Nat Commun. 2014 Sep 18;5:4974
pubmed: 25232639
Science. 2002 Oct 25;298(5594):830-4
pubmed: 12399591
Gait Posture. 2009 Jan;29(1):36-41
pubmed: 18656361
Skelet Muscle. 2020 Oct 22;10(1):30
pubmed: 33092650
World J Diabetes. 2015 Jul 25;6(8):1073-81
pubmed: 26240704
Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3508-3517
pubmed: 30755520
Mech Ageing Dev. 2009 Nov-Dec;130(11-12):762-70
pubmed: 19896965
J Child Neurol. 2015 Sep;30(10):1275-80
pubmed: 25414237
Hum Mol Genet. 2018 Aug 1;27(R2):R163-R172
pubmed: 29771317
Sci Rep. 2020 Oct 1;10(1):16190
pubmed: 33004810
FASEB J. 2008 Aug;22(8):3046-58
pubmed: 18460651
Br J Pharmacol. 2014 Apr;171(8):2099-122
pubmed: 23991830
Mol Cell Biol. 2013 Mar;33(6):1104-13
pubmed: 23297346
Front Physiol. 2020 Jun 19;11:690
pubmed: 32636760
Dis Model Mech. 2020 Mar 2;13(2):
pubmed: 32224496
Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4494-9
pubmed: 15767565
Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165674
pubmed: 31926263
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19024-9
pubmed: 24191049
EMBO J. 2010 Sep 15;29(18):3184-95
pubmed: 20700105
Lab Chip. 2018 Jul 24;18(15):2187-2201
pubmed: 29892747
Front Genet. 2018 Apr 10;9:114
pubmed: 29692797
Aging Cell. 2020 Oct;19(10):e13223
pubmed: 32857472
Front Pharmacol. 2017 Aug 23;8:548
pubmed: 28878670
Neuromuscul Disord. 2004 Jun;14(6):365-70
pubmed: 15145337
Nitric Oxide. 2014 Sep 15;41:120-30
pubmed: 24755204
PLoS Comput Biol. 2014 Jul 17;10(7):e1003702
pubmed: 25033081
J Pediatr Rehabil Med. 2016;9(1):5-11
pubmed: 26966795
Gene. 2001 Jan 24;263(1-2):103-12
pubmed: 11223248
Aging (Albany NY). 2018 Nov 19;10(11):3382-3396
pubmed: 30455409
Int J Mol Sci. 2020 Jun 28;21(13):
pubmed: 32605223
Pharmacol Res. 2016 Nov;113(Pt A):186-198
pubmed: 27565382
PLoS One. 2011;6(11):e26952
pubmed: 22096509
Neurogenetics. 1998 Dec;2(1):61-72
pubmed: 9933302
Science. 1998 Dec 11;282(5396):2012-8
pubmed: 9851916
Redox Biol. 2021 Jan;38:101772
pubmed: 33137711
J Child Neurol. 2010 Sep;25(9):1103-9
pubmed: 20587736
Orphanet J Rare Dis. 2017 Apr 26;12(1):79
pubmed: 28446219
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2943-8
pubmed: 22323590
Med Hypotheses. 2015 Dec;85(6):1021-33
pubmed: 26365249
Bosn J Basic Med Sci. 2015 Jul 20;15(3):14-20
pubmed: 26295289
Lab Chip. 2012 Jun 21;12(12):2211-20
pubmed: 22588281
Sci Transl Med. 2016 Oct 19;8(361):361ra139
pubmed: 27798264
Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):607-18
pubmed: 20470749
Pharmacol Ther. 2020 Oct 29;:107719
pubmed: 33130193
WormBook. 2017 Apr 13;2017:1-59
pubmed: 27555356
Nature. 2002 Oct 24;419(6909):808-14
pubmed: 12397350
J Vis Exp. 2014 Nov 13;(93):e52043
pubmed: 25489753
FASEB J. 2015 Apr;29(4):1235-46
pubmed: 25491313
PLoS One. 2013 Nov 08;8(11):e80135
pubmed: 24260346
Dis Model Mech. 2018 Dec 4;11(12):
pubmed: 30396907
Antioxid Redox Signal. 2014 Jun 1;20(16):2621-30
pubmed: 24093496