Genetic variants for morningness in relation to habitual sleep-wake behavior and diurnal preference in a population-based sample of 17,243 adults.
Chronotype
Eveningness
MEQ
Polygenic risk score
Population-based
Sleep midpoint
Journal
Sleep medicine
ISSN: 1878-5506
Titre abrégé: Sleep Med
Pays: Netherlands
ID NLM: 100898759
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
05
11
2020
accepted:
27
01
2021
pubmed:
26
2
2021
medline:
6
7
2021
entrez:
25
2
2021
Statut:
ppublish
Résumé
Associations of eveningness with health hazards benefit from analyzing to what extent the polygenic score for morningness correlates with the assessments of the behavioral trait of morningness-eveningness and chronotype. With a population-based sample of 17,243 Finnish adults, aged 25-74 years, this study examines the associations of four feasible assessment methods of chronotype, a) biological the genetic liability based on the polygenic score for morningness (PGS All self-report measures correlated with each other, but very weakly with the PGS The current polygenic score for morningness explains only a small proportion of the variation in diurnal preference or habitual sleep-wake schedule. The molecular genetic basis for morningness-eveningness needs further elucidation.
Identifiants
pubmed: 33631501
pii: S1389-9457(21)00071-X
doi: 10.1016/j.sleep.2021.01.054
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
322-332Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.