T Cell Repertoire During Ontogeny and Characteristics in Inflammatory Disorders in Adults and Childhood.
T cell immunity
allergy
autoimmune disorders
clonality
diversity
immune deficiencies
next generation sequencing
ontogeny
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
09
2020
accepted:
22
12
2020
entrez:
26
2
2021
pubmed:
27
2
2021
medline:
23
6
2021
Statut:
epublish
Résumé
Since the first day of life, a newborn has to deal with various pathogens from the environment. While passive immune protection is provided by diaplacental maternal antibodies, the development of cellular immunity is ongoing. A mature immune system should be able not only to defend against pathogens, but should also be able to differentiate between self- and non-self-antigens. Dysregulation in the development of cellular immunity can lead to severe disorders like immunodeficiency, autoimmunity and chronic inflammation. In this review, we explain the role of T cell immunity in antigen detection and summarize the characteristics of a mature TCR repertoire as well as the current state of knowledge about the development of the TCR repertoire in ontogenesis. In addition, methods of assessments are outlined, with a focus on the advantages and disadvantages of advanced methods such as next generation sequencing. Subsequently, we provide an overview of various disorders occuring in early childhood like immunodeficiencies, autoimmunity, allergic diseases and chronic infections and outline known changes in the TCR repertoire. Finally, we summarize the latest findings and discuss current research gaps as well as potential future developments.
Identifiants
pubmed: 33633732
doi: 10.3389/fimmu.2020.611573
pmc: PMC7899981
doi:
Substances chimiques
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
611573Informations de copyright
Copyright © 2021 Foth, Völkel, Bauersachs, Zemlin and Skevaki.
Déclaration de conflit d'intérêts
For CS: Consultancy and research funding, Hycor Biomedical and Thermo Fisher Scientific; Research Funding, Mead Johnson Nutrition (MJN); Consultancy, Bencard Allergie. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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