IL-4 and IL-17 Are Required for House Dust Mite-Driven Airway Hyperresponsiveness in Autoimmune Diabetes-Prone Non-Obese Diabetic Mice.
IL-17
IL-4
NOD mice
airway hyperreactivity
asthma
house dust mite
iNKT cells
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
08
2020
accepted:
29
12
2020
entrez:
1
3
2021
pubmed:
2
3
2021
medline:
22
6
2021
Statut:
epublish
Résumé
Allergic asthma is characterized by airway inflammation with a Th2-type cytokine profile, hyper-IgE production, mucus hypersecretion, and airway hyperreactivity (AHR). It is increasingly recognized that asthma is a heterogeneous disease implicating complex immune mechanisms resulting in distinct endotypes observed in patients. In this study, we showed that non-obese diabetic (NOD) mice, which spontaneously develop autoimmune diabetes, undergo more severe allergic asthma airway inflammation and AHR than pro-Th2 BALB/c mice upon house dust mite (HDM) sensitization and challenge. The use of IL-4-deficient NOD mice and the
Identifiants
pubmed: 33643284
doi: 10.3389/fimmu.2020.595003
pmc: PMC7904896
doi:
Substances chimiques
Il17a protein, mouse
0
Il4 protein, mouse
0
Interleukin-17
0
Interleukin-4
207137-56-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
595003Informations de copyright
Copyright © 2021 Foray, Dietrich, Pecquet, Machavoine, Chatenoud and Leite-de-Moraes.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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