The Peripheral Blood Transcriptome Is Correlated With PET Measures of Lung Inflammation During Successful Tuberculosis Treatment.


Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2020
Historique:
received: 18 08 2020
accepted: 22 12 2020
entrez: 1 3 2021
pubmed: 2 3 2021
medline: 29 6 2021
Statut: epublish

Résumé

Pulmonary tuberculosis (PTB) is characterized by lung granulomas, inflammation and tissue destruction. Here we used within-subject peripheral blood gene expression over time to correlate with the within-subject lung metabolic activity, as measured by positron emission tomography (PET) to identify biological processes and pathways underlying overall resolution of lung inflammation. We used next-generation RNA sequencing and [

Identifiants

pubmed: 33643286
doi: 10.3389/fimmu.2020.596173
pmc: PMC7902901
doi:

Substances chimiques

Biomarkers 0
Cell-Free Nucleic Acids 0
Transcription Factors 0
Fluorodeoxyglucose F18 0Z5B2CJX4D

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

596173

Investigateurs

André G Loxton (AG)
Annare Ellman (A)
Bronwyn Smith (B)
Caroline G G Beltran (CGG)
Clifton E Barry (CE)
David Alland (D)
Friedrich Thienemann (F)
Gerard Tromp (G)
Gerhard Walzl (G)
James M Warwick (JM)
Jill Winter (J)
Katharina Ronacher (K)
Kim Stanley (K)
Ilse Kant (I)
Lani Thiart (L)
Lance A Lucas (LA)
Laura E Via (LE)
Lori E Dodd (LE)
Magdalena Kriel (M)
Nelita Plessis Du (N)
Patrick Dupont (P)
Ray Y Chen (RY)
Robert J Wilkinson (RJ)
Shubhada Shenai (S)
Stephanie Griffith-Richards (S)
Stephanus T Malherbe (ST)

Informations de copyright

Copyright © 2021 Odia, Malherbe, Meier, Maasdorp, Kleynhans, du Plessis, Loxton, Zak, Thompson, Duffy, Kuivaniemi, Ronacher, Winter, Walzl, Tromp and the Catalysis TB-Biomarker Consortium.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Indian J Nucl Med. 2017 Oct-Dec;32(4):316-321
pubmed: 29142348
Cell Host Microbe. 2015 Jun 10;17(6):799-810
pubmed: 26048138
Am J Respir Crit Care Med. 2011 Nov 15;184(10):1153-63
pubmed: 21852540
PLoS Pathog. 2017 Nov 16;13(11):e1006687
pubmed: 29145483
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Clin Chem. 2009 May;55(5):994-1001
pubmed: 19282357
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Biometrics. 1996 Dec;52(4):1165-82
pubmed: 8962448
Eur Radiol. 2012 Sep;22(9):1946-54
pubmed: 22538627
EJNMMI Res. 2018 Jun 25;8(1):55
pubmed: 29943161
Nat Protoc. 2009;4(8):1184-91
pubmed: 19617889
Yale J Biol Med. 2010 Jun;83(2):53-65
pubmed: 20589185
JAMA Netw Open. 2018 Oct 5;1(6):e183779
pubmed: 30646264
J Physiol. 2017 May 1;595(9):2779-2780
pubmed: 28217967
J Clin Epidemiol. 2010 Jul;63(7):721-7
pubmed: 20338724
PLoS Med. 2019 Apr 23;16(4):e1002786
pubmed: 31013272
Oncotarget. 2017 Jan 10;8(2):2037-2043
pubmed: 27682872
Immunology. 2003 Dec;110(4):411-20
pubmed: 14632637
Lancet Respir Med. 2020 Apr;8(4):395-406
pubmed: 31958400
Respir Med. 2013 Mar;107(3):439-47
pubmed: 23261309
Eur J Nucl Med Mol Imaging. 2014 Jan;41(1):21-31
pubmed: 23990143
Trends Biochem Sci. 2002 Jul;27(7):344-51
pubmed: 12114023
Nucleic Acids Res. 2019 Jul 2;47(W1):W199-W205
pubmed: 31114916
BMC Pulm Med. 2013 Mar 21;13:14
pubmed: 23514625
PLoS One. 2016 Aug 10;11(8):e0160062
pubmed: 27508390
AJR Am J Roentgenol. 2010 Aug;195(2):292-300
pubmed: 20651183
Int J Infect Dis. 2015 Mar;32:87-93
pubmed: 25809762
J Korean Med Sci. 2016 Jan;31(1):39-46
pubmed: 26770036
Nature. 2010 Aug 19;466(7309):973-7
pubmed: 20725040
Front Immunol. 2018 Jan 12;8:1949
pubmed: 29375572
Nat Methods. 2015 May;12(5):453-7
pubmed: 25822800
Nature. 2018 Aug;560(7720):644-648
pubmed: 30135583
Nucleic Acids Res. 2009 Jan;37(Database issue):D623-8
pubmed: 18940869
J Clin Epidemiol. 2006 Oct;59(10):1102-9
pubmed: 16980151
Behav Res Methods. 2017 Aug;49(4):1494-1502
pubmed: 27620283
BMC Bioinformatics. 2017 Mar 4;18(1):151
pubmed: 28259142
Circulation. 2002 Sep 3;106(10):1199-204
pubmed: 12208793
Nucleic Acids Res. 2011 Jan;39(Database issue):D712-7
pubmed: 21071422
PLoS One. 2015 Jul 02;10(7):e0132249
pubmed: 26133981
J Proteome Res. 2017 Jan 6;16(1):247-263
pubmed: 27760463
J Nucl Med Technol. 2014 Sep;42(3):235-7
pubmed: 24948823
Clin Dev Immunol. 2012;2012:139127
pubmed: 22811737
Tuberculosis (Edinb). 2017 Dec;107:48-58
pubmed: 29050771
Am J Epidemiol. 2012 Feb 1;175(3):210-7
pubmed: 22262640
Mol Cancer. 2019 Mar 30;18(1):60
pubmed: 30925919
J Mol Cell Cardiol. 2011 Feb;50(2):273-9
pubmed: 21047514
J Clin Epidemiol. 2006 Oct;59(10):1092-101
pubmed: 16980150
Tuberc Respir Dis (Seoul). 2015 Apr;78(2):64-71
pubmed: 25861338
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Curr Vasc Pharmacol. 2012 Sep;10(5):555-62
pubmed: 22338570
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Sci Rep. 2020 May 25;10(1):8629
pubmed: 32451443
J Korean Med Sci. 2014 Mar;29(3):386-91
pubmed: 24616588
Nucleic Acids Res. 2018 Jan 4;46(D1):D267-D275
pubmed: 29126285
Adv Immunol. 2011;111:179-206
pubmed: 21970955
Clin Transl Imaging. 2016;4:131-144
pubmed: 27077068
PLoS One. 2013 Aug 05;8(8):e70630
pubmed: 23940611
PLoS One. 2012;7(10):e46191
pubmed: 23056259
Am J Epidemiol. 2018 Mar 1;187(3):568-575
pubmed: 29165572
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
World J Gastroenterol. 2014 Jan 7;20(1):100-9
pubmed: 24415862
Eur J Nucl Med Mol Imaging. 2017 Jan;44(1):50-62
pubmed: 27573638
J Clin Epidemiol. 2006 Oct;59(10):1115-23
pubmed: 16980153
Immun Inflamm Dis. 2016 Dec 27;5(1):57-67
pubmed: 28250925
Hum Mol Genet. 2018 Sep 1;27(17):2965-2977
pubmed: 29790959
Nat Rev Immunol. 2011 May;11(5):343-54
pubmed: 21475309
Mil Med Res. 2020 Jun 3;7(1):25
pubmed: 32493477
Mol Cancer. 2020 Apr 2;19(1):70
pubmed: 32241281
Curr Opin Oncol. 2016 Jan;28(1):65-71
pubmed: 26599292
Clin Microbiol Rev. 2008 Apr;21(2):305-33, table of contents
pubmed: 18400799
Nat Commun. 2018 Nov 9;9(1):4735
pubmed: 30413720
Transl Res. 2017 Jun;184:77-100
pubmed: 28284670
Nucleic Acids Res. 2018 Jan 4;46(D1):D649-D655
pubmed: 29145629
Tumour Biol. 2017 Oct;39(10):1010428317728285
pubmed: 29025377
Nat Med. 2016 Oct;22(10):1094-1100
pubmed: 27595324
Atherosclerosis. 2006 Aug;187(2):351-62
pubmed: 16253262
Antimicrob Agents Chemother. 2012 Aug;56(8):4391-402
pubmed: 22687508
J Infect Dis. 2013 Jan 1;207(1):18-29
pubmed: 22872737
J Clin Epidemiol. 2006 Oct;59(10):1087-91
pubmed: 16980149
Stat Med. 1998 Mar 15-Apr 15;17(5-7):781-96
pubmed: 9549823
Thorax. 1998 Jul;53(7):601-12
pubmed: 9797762
Lung Cancer. 2009 Aug;65(2):180-6
pubmed: 19155090
J Clin Epidemiol. 2012 Jun;65(6):686-95
pubmed: 22459429
Bioinformatics. 2019 Dec 15;35(24):5146-5154
pubmed: 31165139
EBioMedicine. 2017 Feb;15:112-126
pubmed: 28065665
EJNMMI Res. 2020 Feb 10;10(1):8
pubmed: 32040770
J Comput Biol. 2020 Jan;27(1):121-130
pubmed: 31460784

Auteurs

Trust Odia (T)

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.
DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
Bioinformatics Unit, South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa.
Centre for Bioinformatics and Computational Biology, Stellenbosch University, Stellenbosch, South Africa.

Stephanus T Malherbe (ST)

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.
DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.

Stuart Meier (S)

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.
DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
Bioinformatics Unit, South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa.
Centre for Bioinformatics and Computational Biology, Stellenbosch University, Stellenbosch, South Africa.

Elizna Maasdorp (E)

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.
DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
Bioinformatics Unit, South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa.
Centre for Bioinformatics and Computational Biology, Stellenbosch University, Stellenbosch, South Africa.

Léanie Kleynhans (L)

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.
DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.

Nelita du Plessis (N)

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.
DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.

Andre G Loxton (AG)

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.
DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.

Daniel E Zak (DE)

Center for Infectious Disease Research, Seattle, WA, United States.

Ethan Thompson (E)

Center for Infectious Disease Research, Seattle, WA, United States.

Fergal J Duffy (FJ)

Center for Infectious Disease Research, Seattle, WA, United States.
Seattle Children's Research Institute, Center for Global Infectious Disease Research, Seattle, WA, United States.

Helena Kuivaniemi (H)

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.
DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.

Katharina Ronacher (K)

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.
DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
Translational Research Institute, Mater Research Institute - The University of Queensland, Brisbane, QLD, Australia.

Jill Winter (J)

Catalysis Foundation for Health, San Ramon, CA, United States.

Gerhard Walzl (G)

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.
DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
Bioinformatics Unit, South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa.

Gerard Tromp (G)

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa.
DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
Bioinformatics Unit, South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa.
Centre for Bioinformatics and Computational Biology, Stellenbosch University, Stellenbosch, South Africa.

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