Genome wide association study of HTLV-1-associated myelopathy/tropical spastic paraparesis in the Japanese population.

Chromosome Mapping Genome-Wide Association Study HLA Antigens / genetics Human T-lymphotropic virus 1 / isolation & purification Humans Japan Paraparesis, Tropical Spastic / genetics Polymorphism, Single Nucleotide Viral Load

HAM/TSP HLA HTLV-1 genome-wide association study proviral load

Journal

Proceedings of the National Academy of Sciences of the United States of America

ISSN: 1091-6490

Titre abrégé: Proc Natl Acad Sci U S A

Pays: United States

ID NLM: 7505876

Informations de publication

Date de publication:
16 03 2021

Historique:

entrez: 2 3 2021

pubmed: 3 3 2021

medline: 15 9 2021

Statut: ppublish

Résumé

HTLV-1-associated myelopathy (HAM/TSP) is a chronic and progressive inflammatory disease of the central nervous system. The aim of our study was to identify genetic determinants related to the onset of HAM/TSP in the Japanese population. We conducted a genome-wide association study comprising 753 HAM/TSP patients and 899 asymptomatic HTLV-1 carriers. We also performed comprehensive genotyping of

Identifiants

DOI: 10.1073/pnas.2004199118 PMID: 33649182 PMC: PMC7980450

pubmed: 33649182

pii: 2004199118

doi: 10.1073/pnas.2004199118

pmc: PMC7980450

pii:

doi:

Substances chimiques

HLA Antigens 0

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Informations de copyright

Déclaration de conflit d'intérêts

Competing interest statement: S.K. and F.M. are board members of GenoConcierge Kyoto Inc. S.K., M. Shimizu, and F.M. have patents pending for HLA typing software, primer sets for PCR amplification of HLA genes and its experimental protocol, and a risk marker of DRB1-GB-7 for HAM/TSP development.

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