A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice.

Animals Antibody Formation B-Lymphocytes / immunology Common Variable Immunodeficiency / genetics HEK293 Cells Haploinsufficiency Heat Shock Transcription Factors / genetics Humans Ikaros Transcription Factor / genetics Immunoglobulins / metabolism Mice Mice, Inbred C57BL Mice, Mutant Strains NIH 3T3 Cells Point Mutation / genetics

Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
01 04 2021
Historique:
received: 10 12 2019
accepted: 27 01 2021
pubmed: 5 3 2021
medline: 25 8 2021
entrez: 4 3 2021
Statut: ppublish

Résumé

IKZF1 (IKAROS) is essential for normal lymphopoiesis in both humans and mice. Previous

Identifiants

DOI: 10.4049/jimmunol.1901464 PMID: 33658297 PMC: PMC7987828
pubmed: 33658297
pii: jimmunol.1901464
doi: 10.4049/jimmunol.1901464
pmc: PMC7987828
mid: NIHMS1669208
doi:

Substances chimiques

Heat Shock Transcription Factors 0
Hsf1 protein, mouse 0
Immunoglobulins 0
Ikaros Transcription Factor 148971-36-2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1505-1514

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI052127
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI100627
Pays : United States

Informations de copyright

Copyright © 2021 by The American Association of Immunologists, Inc.

Références

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Auteurs

Brigette Boast (B)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
ORCID: 0000-0003-0089-7551

Lisa A Miosge (LA)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.

Hye Sun Kuehn (HS)

Immunology Service, Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD 20892.

Vicky Cho (V)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
ORCID: 0000-0001-9039-9876

Vicki Athanasopoulos (V)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
Centre for Personalised Immunology, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
ORCID: 0000-0002-5764-5948

Hayley A McNamara (HA)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
ORCID: 0000-0001-6347-6215

Yovina Sontani (Y)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
ORCID: 0000-0001-9553-5304

Yan Mei (Y)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.

Debbie Howard (D)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.

Henry J Sutton (HJ)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
ORCID: 0000-0002-6472-7116

Sofia A Omari (SA)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
Children's Cancer Institute, School of Women's and Children's Health, Lowy Cancer Centre, University of New South Wales, Sydney, New South Wales 2031, Australia.

Zhijia Yu (Z)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
ORCID: 0000-0002-4763-4698

Mariam Nasreen (M)

Australian Phenomics Facility, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia; and.
ORCID: 0000-0001-9111-9717

T Daniel Andrews (TD)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.

Ian A Cockburn (IA)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
ORCID: 0000-0001-8220-9294

Christopher C Goodnow (CC)

Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
ORCID: 0000-0001-5296-6155

Sergio D Rosenzweig (SD)

Immunology Service, Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD 20892.

Anselm Enders (A)

Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia; anselm.enders@anu.edu.au.
ORCID: 0000-0001-5933-6463

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A Point Mutation in IKAROS ZF1 Causes a B Cell...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité active › Production d'anticorps › A Point Mutation in IKAROS ZF1 Causes a B Cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › A Point Mutation in IKAROS ZF1 Causes a B Cell...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Déficit immunitaire commun variable › A Point Mutation in IKAROS ZF1 Causes a B Cell...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › A Point Mutation in IKAROS ZF1 Causes a B Cell...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Dosage génique › Haploinsuffisance › A Point Mutation in IKAROS ZF1 Causes a B Cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription de choc thermique › A Point Mutation in IKAROS ZF1 Causes a B Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A Point Mutation in IKAROS ZF1 Causes a B Cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription Krüppel-like › Facteur de transcription Ikaros › A Point Mutation in IKAROS ZF1 Causes a B Cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › A Point Mutation in IKAROS ZF1 Causes a B Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A Point Mutation in IKAROS ZF1 Causes a B Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › A Point Mutation in IKAROS ZF1 Causes a B Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › A Point Mutation in IKAROS ZF1 Causes a B Cell...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Cellules 3T3 › Cellules NIH 3T3 › A Point Mutation in IKAROS ZF1 Causes a B Cell...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation ponctuelle › A Point Mutation in IKAROS ZF1 Causes a B Cell...