Gut dysbiosis and mortality in hemodialysis patients.

Aged Aged, 80 and over Bacteria / classification Case-Control Studies Dysbiosis / epidemiology Feces / microbiology Female Gastrointestinal Microbiome Humans Male Middle Aged Phylogeny Prognosis RNA, Ribosomal, 16S / genetics Renal Dialysis / mortality Renal Insufficiency, Chronic / microbiology Sequence Analysis, DNA

Journal

NPJ biofilms and microbiomes
ISSN: 2055-5008
Titre abrégé: NPJ Biofilms Microbiomes
Pays: United States
ID NLM: 101666944

Informations de publication

Date de publication:
03 03 2021
Historique:
received: 14 06 2020
accepted: 27 01 2021
entrez: 4 3 2021
pubmed: 5 3 2021
medline: 23 9 2021
Statut: epublish

Résumé

Little is known about the relationship between gut dysbiosis, inflammation, and adverse outcomes in patients with chronic kidney disease. We examined the association of microbial diversity with all-cause mortality in hemodialysis patients. The gut microbiota was assessed by 16S ribosomal RNA gene sequencing. During a median follow-up of 2.1 years, the adjusted risk of death among patients with higher diversity (above median) was 74% lower than that among patients with lower diversity (below median). We then compared the microbial composition between nonsurvivors and survivors in a matched case-control study. We observed significantly lower microbial diversity and higher proinflammatory cytokines among nonsurvivors than survivors. Specifically, the relative abundance of Succinivibrio and Anaerostipes, two short-chain fatty acid-producing bacteria, was markedly reduced in nonsurvivors. Thus, a unique gut microbial composition is associated with an increased risk of mortality among hemodialysis patients and may be used to identify subjects with a poor prognosis.

Identifiants

DOI: 10.1038/s41522-021-00191-x PMID: 33658514 PMC: PMC7930281
pubmed: 33658514
doi: 10.1038/s41522-021-00191-x
pii: 10.1038/s41522-021-00191-x
pmc: PMC7930281
doi:

Substances chimiques

RNA, Ribosomal, 16S 0

Banques de données

Dryad
['10.5061/dryad.k3j9kd55d']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

20

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Auteurs

Ting-Yun Lin (TY)

Division of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi University, Hualien, Taiwan.

Ping-Hsun Wu (PH)

Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Yi-Ting Lin (YT)

Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Szu-Chun Hung (SC)

Division of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi University, Hualien, Taiwan. szuchun.hung@gmail.com.
ORCID: 0000-0002-6037-398X

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Gut dysbiosis and mortality in hemodialysis patients.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Gut dysbiosis and mortality in hemodialysis patients.
questionsmedicales.fr › Bactéries › Gut dysbiosis and mortality in hemodialysis patients.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Gut dysbiosis and mortality in hemodialysis patients.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Dysbiose › Gut dysbiosis and mortality in hemodialysis patients.
questionsmedicales.fr › Liquides et sécrétions biologiques › Fèces › Gut dysbiosis and mortality in hemodialysis patients.
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Gut dysbiosis and mortality in hemodialysis patients.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gut dysbiosis and mortality in hemodialysis patients.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Gut dysbiosis and mortality in hemodialysis patients.
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Gut dysbiosis and mortality in hemodialysis patients.
questionsmedicales.fr › Diagnostic › Pronostic › Gut dysbiosis and mortality in hemodialysis patients.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN ribosomique › ARN ribosomique 16S › Gut dysbiosis and mortality in hemodialysis patients.
questionsmedicales.fr › Thérapeutique › Détoxication par sorption › Dialyse rénale › Gut dysbiosis and mortality in hemodialysis patients.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Insuffisance rénale chronique › Gut dysbiosis and mortality in hemodialysis patients.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Gut dysbiosis and mortality in hemodialysis patients.