Molecular Insights into an Antibiotic Enhancer Action of New Morpholine-Containing 5-Arylideneimidazolones in the Fight against MDR Bacteria.
Allosteric Site
Anti-Bacterial Agents
/ chemical synthesis
Bacteria
/ drug effects
Crystallography, X-Ray
Drug Evaluation, Preclinical
Drug Interactions
Drug Resistance, Multiple, Bacterial
/ drug effects
Hydrogen Bonding
Hydrogen-Ion Concentration
Imidazoles
/ chemical synthesis
Ligands
Microbial Sensitivity Tests
Molecular Conformation
Molecular Docking Simulation
Morpholines
/ chemical synthesis
Solubility
Structure-Activity Relationship
Water
5-arylideneimidazolones
AcrAB-TolC
Klebsiella aerogenes
MRSA
PBP2a
RTE assay
Staphylococcus aureus
antibiotic adjuvant
molecular docking
multidrug resistance
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Feb 2021
19 Feb 2021
Historique:
received:
29
01
2021
revised:
11
02
2021
accepted:
13
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
17
4
2021
Statut:
epublish
Résumé
In the search for an effective strategy to overcome antimicrobial resistance, a series of new morpholine-containing 5-arylideneimidazolones differing within either the amine moiety or at position five of imidazolones was explored as potential antibiotic adjuvants against Gram-positive and Gram-negative bacteria. Compounds (
Identifiants
pubmed: 33669790
pii: ijms22042062
doi: 10.3390/ijms22042062
pmc: PMC7922564
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Imidazoles
0
Ligands
0
Morpholines
0
Water
059QF0KO0R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerstwo Nauki i Szkolnictwa Wyższego
ID : "Diamond Grant" no 0169/DIA/2017/46
Organisme : Uniwersytet Jagielloński Collegium Medicum
ID : N42/DBS/000070
Organisme : Uniwersytet Jagielloński Collegium Medicum
ID : N42/DBS/000027
Organisme : Uniwersytet Jagielloński Collegium Medicum
ID : N42/DBS/000093
Organisme : Wydział Lekarski, Uniwersytet Jagielloński Collegium Medicum
ID : N42/DBS/000096
Organisme : Uniwersytet Jagielloński Collegium Medicum
ID : N42/DBS/000165 and N42/DBS/000162
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