Antiviral Cytokine Response in Neuroinvasive and Non-Neuroinvasive West Nile Virus Infection.
West Nile fever
West Nile virus
immune response
neuro-invasive disease
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
22 02 2021
22 02 2021
Historique:
received:
14
01
2021
revised:
14
02
2021
accepted:
19
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
13
8
2021
Statut:
epublish
Résumé
Data on the immune response to West Nile virus (WNV) are limited. We analyzed the antiviral cytokine response in serum and cerebrospinal fluid (CSF) samples of patients with WNV fever and WNV neuroinvasive disease using a multiplex bead-based assay for the simultaneous quantification of 13 human cytokines. The panel included cytokines associated with innate and early pro-inflammatory immune responses (TNF-α/IL-6), Th1 (IL-2/IFN-γ), Th2 (IL-4/IL-5/IL-9/IL-13), Th17 immune response (IL-17A/IL-17F/IL-21/IL-22) and the key anti-inflammatory cytokine IL-10. Elevated levels of IFN-γ were detected in 71.7% of CSF and 22.7% of serum samples (
Identifiants
pubmed: 33671821
pii: v13020342
doi: 10.3390/v13020342
pmc: PMC7927094
pii:
doi:
Substances chimiques
Cytokines
0
IL17F protein, human
0
IL4 protein, human
0
Interleukin-17
0
Interleukin-4
207137-56-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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