Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.
Adipose Tissue
/ metabolism
Animals
Cells, Cultured
Fatty Acids
/ metabolism
Humans
Inflammation
/ pathology
Lipid Metabolism
Liver
/ pathology
Macrophages
/ metabolism
Male
Membrane Proteins
/ deficiency
Mice, Inbred C57BL
Mice, Knockout
Monoacylglycerol Lipases
/ deficiency
Non-alcoholic Fatty Liver Disease
/ enzymology
Oleic Acid
Phenotype
U937 Cells
Weight Gain
MGL
NAFLD
NASH
PNPLA3
inflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Feb 2021
20 Feb 2021
Historique:
received:
12
01
2021
revised:
29
01
2021
accepted:
02
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
15
4
2021
Statut:
epublish
Résumé
Altered lipid metabolic pathways including hydrolysis of triglycerides are key players in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Whether adiponutrin (patatin-like phospholipase domain containing protein-3-PNPLA3) and monoacylglycerol lipase (MGL) synergistically contribute to disease progression remains unclear. We generated double knockout (
Identifiants
pubmed: 33672787
pii: ijms22042126
doi: 10.3390/ijms22042126
pmc: PMC7924608
pii:
doi:
Substances chimiques
Fatty Acids
0
Membrane Proteins
0
adiponutrin
0
Oleic Acid
2UMI9U37CP
Monoacylglycerol Lipases
EC 3.1.1.23
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Austrian Science Fund
ID : F7310-B21
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