Cardioprotective Properties of Mannitol-Involvement of Mitochondrial Potassium Channels.
Animals
Male
Rats
Cardiotonic Agents
/ pharmacology
Diuretics, Osmotic
/ pharmacology
Ischemic Preconditioning, Myocardial
/ methods
Mannitol
/ pharmacology
Myocardial Infarction
/ drug therapy
Myocardial Reperfusion Injury
/ drug therapy
Potassium Channels
/ metabolism
Random Allocation
Rats, Wistar
mannitol
myocardial infarction
osmolarity
postconditioning
preconditioning
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Feb 2021
27 Feb 2021
Historique:
received:
13
01
2021
revised:
15
02
2021
accepted:
24
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
11
5
2021
Statut:
epublish
Résumé
Cardiac preconditioning (PC) and postconditioning (PoC) are powerful measures against the consequences of myocardial ischemia and reperfusion (I/R) injury. Mannitol-a hyperosmolar solution-is clinically used for treatment of intracranial and intraocular pressure or promotion of diuresis in renal failure. Next to these clinical indications, different organ-protective properties-e.g., perioperative neuroprotection-are described. However, whether Mannitol also confers cardioprotection via a pre- and/or postconditioning stimulus, possibly reducing consequences of I/R injury, remains to be seen. Therefore, in the present study we investigated whether (1) Mannitol-induced pre- and/or postconditioning induces myocardial infarct size reduction and (2) activation of mitochondrial ATP-sensitive potassium (mK
Identifiants
pubmed: 33673646
pii: ijms22052395
doi: 10.3390/ijms22052395
pmc: PMC7957595
pii:
doi:
Substances chimiques
Cardiotonic Agents
0
Diuretics, Osmotic
0
Mannitol
3OWL53L36A
mitochondrial K(ATP) channel
0
Potassium Channels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Physiol Res. 2016 Dec 13;65(6):1045-1051
pubmed: 27959577
Physiol Res. 1999;48(5):331-40
pubmed: 10625222
Anesth Analg. 2020 Dec;131(6):1765-1780
pubmed: 33186163
PeerJ. 2016 Feb 16;4:e1706
pubmed: 26925330
Biochim Biophys Acta. 2011 Jul;1813(7):1316-22
pubmed: 21295622
J Nephrol. 2019 Aug;32(4):539-547
pubmed: 30635875
Thorac Cardiovasc Surg. 1999 Feb;47(1):58-62
pubmed: 10218625
Drug Res (Stuttg). 2019 Jul;69(7):365-373
pubmed: 30609434
Circulation. 1985 Sep;72(3 Pt 2):II254-8
pubmed: 3928190
Anesth Analg. 2008 Jan;106(1):17-23, table of contents
pubmed: 18165546
Nature. 2019 Aug;572(7771):609-613
pubmed: 31435016
J Mol Cell Cardiol. 2003 Apr;35(4):339-41
pubmed: 12689812
Exp Ther Med. 2015 Dec;10(6):2197-2205
pubmed: 26668616
Int J Mol Sci. 2019 Aug 16;20(16):
pubmed: 31426434
Heart Fail Rev. 2007 Dec;12(3-4):249-60
pubmed: 17516167
Am J Physiol Heart Circ Physiol. 2002 Jul;283(1):H284-95
pubmed: 12063301
Biochim Biophys Acta. 2011 Jul;1813(7):1309-15
pubmed: 21094666
J Cardiovasc Pharmacol. 2018 Aug;72(2):106-111
pubmed: 29787401
Circulation. 1984 Sep;70(3 Pt 2):I91-5
pubmed: 6086178
Cardiovasc Res. 1993 Sep;27(9):1555-63
pubmed: 8287430
Circ Res. 2015 Feb 13;116(4):674-99
pubmed: 25677517
World J Cardiol. 2011 Jun 26;3(6):186-200
pubmed: 21772945
J Neurosci Nurs. 1994 Jun;26(3):170-4
pubmed: 7963823
Basic Res Cardiol. 2016 Nov;111(6):70
pubmed: 27766474
Am J Physiol. 1992 Mar;262(3 Pt 2):H641-8
pubmed: 1558171
J Mol Cell Cardiol. 2005 Jul;39(1):7-16
pubmed: 15978901
Basic Res Cardiol. 1985 May-Jun;80(3):251-9
pubmed: 3927894
Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H921-30
pubmed: 12915383
Mol Cell Biochem. 2005 Jan;269(1-2):59-67
pubmed: 15786717
Crit Care Med. 2015 Oct;43(10):2212-8
pubmed: 26121074
PLoS One. 2015 Dec 15;10(12):e0144737
pubmed: 26671662
Biochem J. 2017 Jun 9;474(12):2067-2094
pubmed: 28600454
Int J Biochem Cell Biol. 2020 Aug;125:105792
pubmed: 32574707
Curr Opin Crit Care. 2019 Apr;25(2):105-109
pubmed: 30676327
Nurs Clin North Am. 2017 Jun;52(2):249-260
pubmed: 28478873
Anal Biochem. 2018 Jul 1;552:50-59
pubmed: 28711444
Circulation. 2005 Jan 18;111(2):198-203
pubmed: 15623543
Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1215-H1231
pubmed: 30004243
J Clin Med. 2020 May 13;9(5):
pubmed: 32413983
J Clin Med. 2020 Mar 24;9(3):
pubmed: 32214047
J Card Surg. 1993 Mar;8(2 Suppl):275-8
pubmed: 8384901
Life Sci. 2011 Jun 6;88(23-24):1026-30
pubmed: 21443891
Surgery. 1983 Sep;94(3):423-7
pubmed: 6412380